Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder.
Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder.
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DOI：
10.1192/bjp.bp.110.090217
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Lenze EJ
中科院分区：
文献类型：
--
作者：
Butters MA;Bhalla RK;Andreescu C;Wetherell JL;Mantella R;Begley AE;Lenze EJ
老年人的广泛性焦虑症（GAD）与神经心理障碍有关。我们检查了老年GAD患者与精神健康老年人的神经心理功能，并检查了艾司西酞普兰12周安慰剂对照试验期间的变化。160例年龄≥60岁、目前患有GAD的非痴呆受试者和37例无精神病史的对照受试者接受了神经心理学评估。129名GAD参与者在治疗后进行了重新评估。GAD参与者在信息处理速度、工作记忆、抑制、问题解决（包括概念形成和心理灵活性）以及即时和延迟记忆方面的表现比对照组差。神经心理功能与日常功能相关。低认知得分者经历了工作记忆、延迟记忆和视觉空间能力的改善，而那些报告焦虑临床改善的人表现出参与抑制和情景回忆的能力改善。这些改善是适度的，在两种治疗条件下的幅度相似。老年人的广泛性焦虑症与神经心理障碍有关，而神经心理障碍又与功能障碍有关。那些患有广泛性焦虑症的人要么认知能力低下，要么报告治疗后焦虑症的临床改善，显示出多个认知领域的改善。这些发现强调了帮助认知和焦虑症状的治疗的重要性。
Generalized Anxiety Disorder (GAD) in older adults is associated with neuropsychological impairment. We examined neuropsychological functioning in older adults with GAD in comparison to psychiatrically healthy older adults and we examined changes during a 12-week, placebo controlled trial of escitalopram. One hundred-sixty non-demented participants aged ≥60 with current GAD and 37 comparison subjects without psychiatric history underwent neuropsychological assessment. One hundred twenty-nine GAD participants were re-assessed post-treatment. GAD participants performed worse than comparison subjects in information processing speed, working memory, inhibition, problem-solving (including concept formation and mental flexibility), and immediate and delayed memory. Neuropsychological functioning was correlated with everyday functioning. Low cognitive scorers experienced working memory, delayed memory and visuospatial ability improvement and those who reported clinical improvement in anxiety exhibited improvement in the ability to engage inhibition and episodic recall. These improvements were modest and of similar magnitude in both treatment conditions. GAD in older adults is associated with neuropsychological impairments, which are associated with functional impairment. Those with GAD who either have low cognitive performance or report clinical improvement in anxiety post-treatment, show improvement in multiple cognitive domains. These findings underscore the importance of treatments that aid cognition as well as anxiety symptoms.
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影响因子：
7.2
作者：
Le Roux, H;Gatz, M;Wetherell, JL
通讯作者：
Wetherell, JL
DOI：
10.1093/gerona/57.4.m209
发表时间：
2002-04-01
影响因子：
5.1
作者：
Jette, AM;Haley, SM;Ashba, J
通讯作者：
Ashba, J
影响因子：
7.2
作者：
Bierman, EJM;Comijs, HC;Beekman, ATF
通讯作者：
Beekman, ATF
影响因子：
7.6
作者：
INGRAM, RE;KENDALL, PC;RONAN, K
通讯作者：
RONAN, K
影响因子：
7.2
作者：
Mantella, Rose C.;Butters, Meryl A.;Lenze, Eric J.
通讯作者：
Lenze, Eric J.