Long-term effects of traffic-related air pollution on mortality in a Dutch cohort (NLCS-AIR study).
Long-term effects of traffic-related air pollution on mortality in a Dutch cohort (NLCS-AIR study).
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DOI：
10.1289/ehp.10767
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发表时间：
2008-02
影响因子：
10.4
通讯作者：
Brunekreef B
中科院分区：
文献类型：
--
作者：
Beelen R;Hoek G;van den Brandt PA;Goldbohm RA;Fischer P;Schouten LJ;Jerrett M;Hughes E;Armstrong B;Brunekreef B
几项研究发现，长期暴露于空气污染中的城市间差异对死亡率有影响。城市内部对比的影响仍然知之甚少。我们研究了长期暴露于交通相关的空气污染与荷兰队列死亡率之间的关系。我们使用的数据来自一项正在进行的饮食与癌症的队列研究，该研究有120，852名受试者，从1987年到1996年进行了随访。在家庭住址估计黑烟（BS）、二氧化氮、二氧化硫和颗粒物（≤mu;M2.5）的暴露量，以及与交通相关的各种暴露变量。我们在调整了年龄、性别、吸烟和地区社会经济地位的整个队列中进行了考克斯分析。最近道路上的交通强度与死亡率独立相关。相对风险（95%置信区间），BS浓度增加10 μg/m3（第5和第95百分位数之间的差异）为1.05（1.00-1.11）自然死亡，1.04（0.95-1.13），呼吸道癌1.22（0.99-1.50），肺癌1.03（0.88-1.20），以及除心血管癌、呼吸道癌或肺癌以外的死亡率1.04（0.97-1.12）。NO2和PM2.5的结果相似，但未发现SO2的相关性。在整个队列中，与交通相关的空气污染和几个交通暴露变量与死亡率相关。相对风险通常较小。NO2和BS的自然原因和呼吸死亡率之间的相关性具有统计学意义。这些结果进一步证明，长期暴露于环境空气污染与死亡率增加有关。
Several studies have found an effect on mortality of between-city contrasts in long-term exposure to air pollution. The effect of within-city contrasts is still poorly understood. We studied the association between long-term exposure to traffic-related air pollution and mortality in a Dutch cohort. We used data from an ongoing cohort study on diet and cancer with 120,852 subjects who were followed from 1987 to 1996. Exposure to black smoke (BS), nitrogen dioxide, sulfur dioxide, and particulate matter ≤mu;M2.5), as well as various exposure variables related to traffic, were estimated at the home address. We conducted Cox analyses in the full cohort adjusting for age, sex, smoking, and area-level socioeconomic status. Traffic intensity on the nearest road was independently associated with mortality. Relative risks (95% confidence intervals) for a 10-μg/m3 increase in BS concentrations (difference between 5th and 95th percentile) were 1.05 (1.00–1.11) for natural cause, 1.04 (0.95–1.13) for cardiovascular, 1.22 (0.99–1.50) for respiratory, 1.03 (0.88–1.20) for lung cancer, and 1.04 (0.97–1.12) for mortality other than cardiovascular, respiratory, or lung cancer. Results were similar for NO2 and PM2.5, but no associations were found for SO2. Traffic-related air pollution and several traffic exposure variables were associated with mortality in the full cohort. Relative risks were generally small. Associations between natural-cause and respiratory mortality were statistically significant for NO2 and BS. These results add to the evidence that long-term exposure to ambient air pollution is associated with increased mortality.
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影响因子：
37.8
作者：
Pope, CA;Burnett, RT;Godleski, JJ
通讯作者：
Godleski, JJ
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
168.9
作者：
Hoek, G;Brunekreef, B;van den Brandt, PA
通讯作者：
van den Brandt, PA
影响因子：
120.7
作者：
Pope, CA;Burnett, RT;Thurston, GD
通讯作者：
Thurston, GD
影响因子：
4.9
作者：
Filleul, L;Rondeau, V;Baldi, I
通讯作者：
Baldi, I