Cellular chemotaxis induced by wear particles from joint replacements.
Cellular chemotaxis induced by wear particles from joint replacements.
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DOI：
10.1016/j.biomaterials.2010.03.046
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发表时间：
2010-07
期刊：
影响因子：
14
通讯作者：
Ma T
中科院分区：
文献类型：
--
作者：
Goodman SB;Ma T
关节置换周围的骨质破坏(假体周围骨溶解)是一种与过量磨损颗粒的产生有关的不良生物反应。关节置换材料的磨损碎屑会刺激慢性炎症和异物反应，导致破骨细胞分化和成熟增加，并减少骨形成。磨屑可诱导局部和全身炎性细胞向颗粒生成部位转移。最近的研究表明，这种作用主要是由趋化细胞因子(趋化因子)介导的，包括巨噬细胞趋化蛋白-1(MCP-1，又称CCL2)、巨噬细胞抑制蛋白-1(MIP-1)、白介素8(IL-8或CXCL8)等。这些配体沿浓度梯度迁移，与细胞表面的G蛋白连接的跨膜受体相互作用。趋化因子参与先天和获得性免疫反应、血管生成、伤口愈合和组织修复。体外、体内和组织修复研究表明，趋化因子诱导的多形核白细胞和单核/巨噬细胞系细胞穿戴颗粒的系统性运输导致促炎因子的释放和随后的骨丢失。调节趋化因子配体-受体轴是一种潜在的策略，可以减轻关节置换引起的磨损颗粒的不利影响。
The destruction of bone around joint replacements (periprosthetic osteolysis) is an adverse biological response associated with the generation of excessive wear particles. Wear debris from the materials used for joint replacements stimulate a chronic inflammatory and foreign body reaction that leads to increased osteoclast differentiation and maturation, and decreased bone formation. Wear debris induces both local and systemic trafficking of inflammatory cells to the site of particle generation. Recent studies have shown that this effect is mediated primarily by chemotactic cytokines (chemokines) including macrophage chemotactic protein-1 (MCP-1, also known as CCL2), macrophage inhibitory protein-1 (MIP-1), Interleukin-8 (IL-8 or CXCL8) and others. These ligands migrate along a concentration gradient to interact with G-protein-linked transmembrane receptors on the cell surface. Chemokines are involved in the innate and adaptive immune responses, angiogenesis, wound healing and tissue repair. In vitro, in vivo and tissue retrieval studies have shown that chemokine-directed systemic trafficking of polymorphonuclear leukocytes and cells of the monocyte/macrophage lineage to wear particles results in the release of pro-inflammatory factors and subsequent bone loss. Modulation of the chemokine ligand-receptor axis is a potential strategy to mitigate the adverse effects of wear particles from joint replacements.
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影响因子：
14
作者：
Kim, Dong-Hwan;Novak, Matt T.;Reichert, William M.
通讯作者：
Reichert, William M.
影响因子：
3.7
作者：
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通讯作者：
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影响因子：
3.5
作者：
Illgen, Richard Lynn, II;Forsythe, Todd M.;Blanchard, Cheryl R.
通讯作者：
Blanchard, Cheryl R.
DOI：
10.5435/00124635-200800001-00013
发表时间：
2008-01-01
影响因子：
3.2
作者：
Bostrom, Mathias;O'Keefe, Regis
通讯作者：
O'Keefe, Regis
影响因子：
5.5
作者：
Cook, DN
通讯作者：
Cook, DN