Acupuncture modulates resting state hippocampal functional connectivity in Alzheimer disease.
Acupuncture modulates resting state hippocampal functional connectivity in Alzheimer disease.
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针灸调节阿尔茨海默病静息状态海马功能连接
DOI：
10.1371/journal.pone.0091160
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li K
中科院分区：
文献类型：
--
作者：
Wang Z;Liang P;Zhao Z;Han Y;Song H;Xu J;Lu J;Li K
本研究的目的是利用功能磁共振成像（fMRI）研究针刺对阿尔茨海默病（AD）患者海马连接的影响。28名右利手受试者（14名AD患者和14名健康老年人）参加了这项研究。对所有受试者进行临床和神经心理学检查。使用SIEMENS verio 3-Tesla扫描仪进行MRI。fMRI研究采用单区组实验设计。我们首先在最初的3分钟内获得基线静息状态数据，然后在太冲和合谷穴位上进行针刺刺激3分钟。最后，我们在拔针后再采集10分钟的fMRI数据。使用统计参数映射（SPM 5）软件进行预处理和数据分析。使用不同州两组的数据进行双样本t检验。我们发现，在静息状态下，AD患者的几个额叶和颞叶区域的海马连接相对于对照组有所减少。在针刺后的静息状态期间，与第一次静息状态相比，AD患者在大多数这些海马相关区域中显示出增加的连接性。综上所述，本研究将功能磁共振成像技术与传统针刺技术相结合，探讨针刺对AD患者的治疗作用。我们的fMRI研究证实，针刺太冲和合谷可以增强AD患者海马的连接。
Our objective is to clarify the effects of acupuncture on hippocampal connectivity in patients with Alzheimer disease (AD) using functional magnetic resonance imaging (fMRI). Twenty-eight right-handed subjects (14 AD patients and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all subjects. MRI was performed using a SIEMENS verio 3-Tesla scanner. The fMRI study used a single block experimental design. We first acquired baseline resting state data during the initial 3 minutes and then performed acupuncture stimulation on the Tai chong and He gu acupoints for 3 minutes. Last, we acquired fMRI data for another 10 minutes after the needle was withdrawn. The preprocessing and data analysis were performed using statistical parametric mapping (SPM5) software. Two-sample t-tests were performed using data from the two groups in different states. We found that during the resting state, several frontal and temporal regions showed decreased hippocampal connectivity in AD patients relative to control subjects. During the resting state following acupuncture, AD patients showed increased connectivity in most of these hippocampus related regions compared to the first resting state. In conclusion, we investigated the effect of acupuncture on AD patients by combing fMRI and traditional acupuncture. Our fMRI study confirmed that acupuncture at Tai chong and He gu can enhance the hippocampal connectivity in AD patients.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.7
作者：
Bai F;Xie C;Watson DR;Shi Y;Yuan Y;Wang Y;Yue C;Teng Y;Wu D;Zhang Z
通讯作者：
Zhang Z
针刺对轻度认知障碍患者全脑网络影响的 FMRI 连接分析
影响因子：
2.5
作者：
Feng, Yuanyuan;Bai, Lijun;Tian, Jie
通讯作者：
Tian, Jie
影响因子：
4.4
作者：
Goveas, Joseph S.;Xie, Chunming;Ward, B. Douglas;Wu, Zhilin;Li, Wenjun;Franczak, Malgorzata;Jones, Jennifer L.;Antuono, Piero G.;Li, Shi-Jiang
通讯作者：
Li, Shi-Jiang
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V