Measures of adiposity and risk of stroke in China: a result from the Kailuan study.
Measures of adiposity and risk of stroke in China: a result from the Kailuan study.
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DOI：
10.1371/journal.pone.0061665
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Wang A;Wu J;Zhou Y;Guo X;Luo Y;Wu S;Zhao X
本研究的目的是探讨肥胖与男性和女性中风风险之间的关系。我们在开滦研究的94，744名参与者（18-98岁）中研究了肥胖与中风之间的关系。在4年的随访中，记录了1，547例缺血性或出血性中风。肥胖的测量包括体重指数（BMI）、腰围（WC）、腰臀比（WHpR）和腰高比（WHtR）。根据考克斯回归模型计算风险比（HR）和95%置信区间（CI），并使用− 2对数似然法评估各模型拟合。肥胖的每一项测量都与总卒中和缺血性卒中的风险相关，但与出血性卒中无关。校正混杂因素和中间值后，总卒中的HR（比较最高五分位数与最低五分位数的平均值）为BMI 1.34（1.13-1.60），WC 1.26（1.06-1.52），WHpR 1.29（1.08-1.56），WHtR 1.38（1.15-1.66）。BMI、WC、WHpR和WHtR的缺血性卒中HR分别为1.52（1.24-1.88）、1.46（1.17-1.81）、1.40（1.12-1.74）和1.62（1.29-2.04）。每个指数的模型拟合相似。肥胖增加中风和缺血性中风的总风险，但不增加出血性中风的风险。本研究未发现BMI、WC、WHpR和WHtR与卒中发生率之间存在有临床意义的差异。
The objective of this study was to explore the association between adiposity and risk of incident stroke among men and women. We studied the relationship between adiposity and stroke among 94,744 participants (18–98 years old) in the Kailuan study. During a follow-up of 4 years, 1,547 ischemic or hemorrhagic strokes were recorded. Measurements of adiposity included body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR). Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated from Cox regression models and each model fit was assessed using −2log-likelihood. Every measurement of adiposity was associated with the risk for total stroke and ischemic stroke, but not for hemorrhagic stroke. After adjusting for confounders and intermediates, the HR (comparing the mean of the highest quintile with that of the lowest quintile) for total stroke was 1.34(1.13–1.60) for BMI, 1.26(1.06–1.52) for WC, 1.29(1.08–1.56) for WHpR, and 1.38(1.15–1.66) for WHtR. The HR for ischemic stroke was 1.52(1.24–1.88) for BMI, 1.46(1.17–1.81) for WC, 1.40(1.12–1.74) for WHpR, and 1.62(1.29–2.04) for WHtR. The model fit for each of the indices was similar. Adiposity increases the total risk of stroke and ischemic stroke, but not of hemorrhagic stroke. No clinically meaningful differences among the associations between BMI, WC, WHpR, and WHtR and stroke incidence were identified in this study.
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