Intra-renal oxygenation in rat kidneys during water loading: effects of cyclooxygenase (COX) inhibition and nitric oxide (NO) donation.
Intra-renal oxygenation in rat kidneys during water loading: effects of cyclooxygenase (COX) inhibition and nitric oxide (NO) donation.
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DOI：
10.1002/jmri.22253
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发表时间：
2010-08
影响因子：
4.4
通讯作者：
Prasad, Pottumarthi V.
中科院分区：
文献类型：
--
作者：
Ji, Lin;Li, Lu-Ping;Schnitzer, Thomas;Du, Hongyan;Prasad, Pottumarthi V.
通过血氧水平依赖性磁共振成像（BOLD MRI）评价大鼠肾脏水负荷过程中肾内氧合，并研究萘西诺中的一氧化氮供体部分是否可以补偿萘西诺对环氧合酶的抑制作用。将19只雄性Sprague道利大鼠分为三组，通过灌胃给予溶剂、萘普生或萘普生两周。在实验当天，静脉输注含葡萄糖的低渗盐水以诱导水利尿。获得BOLD MRI数据以监测肾氧合，并获得定时尿样以估计前列腺素和尿流量。本研究中的数据与先前在人类中的经验一致，即在水负荷期间，用萘普生预处理消除了髓氧合的改善。此外，那普利西诺德对肾上腺素的抑制作用达到与那普利生相似的水平，但在水负荷过程中维持了肾髓质氧合的改善。这表明，萘普生可能具有较低的肾毒性，并且一氧化氮供体部分部分补偿了萘普生对前列腺素抑制的血液动力学效应。
To evaluate intra-renal oxygenation by blood oxygenation level dependent magnetic resonance imaging (BOLD MRI) in rat kidneys during water-loading and to investigate if the nitric oxide donating moiety in naproxcinod could compensate the effect of cyclooxygenase inhibition of naproxen. Nineteen male Sprague Dawley rats were divided into three groups and dosed with vehicle, naproxen or naproxcinod by gavage for two weeks. On the day of the experiment, hypotonic saline with glucose was infused intravenously to induce water diuresis. BOLD MRI data to monitor renal oxygenation and timed urine samples for estimation of prostaglandins and urine flow were obtained. The data in this study is consistent with previous experience in humans in that pre-treatment with naproxen abolished the improvement in medullary oxygenation during water-loading. In addition, the inhibition of prostaglandins by naproxcinod reached similar levels as naproxen but maintained the improvement in oxygenation in renal medulla during water-loading. This suggests that naproxcinod may have less nephrotoxicity and that the nitric oxide donating moiety partially compensates for the hemodynamic effects of prostaglandin inhibition by naproxen.
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影响因子：
64.8
作者：
AUKLAND, K;KROG, J
通讯作者：
KROG, J
DOI：
10.1007/978-0-387-85998-9_31
发表时间：
2009-01-01
期刊：
OXYGEN TRANSPORT TO TISSUE XXX
影响因子：
--
作者：
Edlund, Jenny;Hansell, Peter;Palm, Fredrik
通讯作者：
Palm, Fredrik
影响因子：
3.4
作者：
Schnitzer, Thomas J.
通讯作者：
Schnitzer, Thomas J.
影响因子：
15.9
作者：
CLARK, JK;BARKER, HG
通讯作者：
BARKER, HG
影响因子：
4.4
作者：
Prasad, PV;Priatna, A;Epstein, FH
通讯作者：
Epstein, FH