Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model
Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model
复制标题
室旁核注射催产素可逆转产后抑郁症大鼠模型的抑郁样行为
DOI：
10.1016/j.bbr.2017.09.012
复制
发表时间：
2018-01
影响因子：
2.7
通讯作者：
Hui Li
中科院分区：
文献类型：
--
作者：
Hui Li
催产素（Oxytocin，OXT）被认为是一种调节社会行为和应激相关疾病的神经调节因子。近年来的临床研究提示OXT对产后抑郁症（PPD）患者也有抗抑郁作用，但其作用机制尚不清楚。本研究探讨了OXT在妊娠束缚应激（GRS）诱导的PPD大鼠模型室旁核（PVN）中的作用及其可能的信号通路。PPD大鼠表现出抑郁样行为，与对照组大鼠相比，不动时间显著延长，攀爬时间缩短，蔗糖消耗量降低。PPD大鼠血浆皮质酮（CORT）水平也较高。而下丘脑室旁核和视上核（SON）是脑内OXT合成的主要区域，GRS诱导的OXT mRNA和肽水平下降仅见于下丘脑室旁核。PPD大鼠室旁核TrkB表达增加。PVN内注射OXT（20 ng）可逆转GRS诱导的PPD大鼠抑郁样行为和高血浆CORT水平。此外，注射OXT也逆转了GRS诱导的PPD大鼠PVN TrkB的增加。以上结果提示，OXT可能通过TrkB调节PPD大鼠下丘脑室旁核HPA轴而发挥抗抑郁作用。
Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders. Recent clinical studies suggest that OXT might also act as antidepressant in postpartum depression (PPD) patients, but the mechanism is still unknown. In the present study, we explored the effect of OXT in paraventricular nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS). PPD rats exhibited depressive-like behaviors with significantly longer immobility time, shorter climbing time, and lower sucrose consumption compared to the control rats. Plasma corticosterone (CORT) level was also higher in PPD rats. While PVN and supraoptic nucleus (SON) are main OXT synthesis regions in the brain, GRS-induced decrease of mRNA and peptide level of OXT was seen only in PVN. The expression of TrkB in PVN was increased in PPD rats. Local injection of OXT (20 ng) into PVN reversed GRS-induced depressive-like behaviors and high plasma CORT level in PPD rats. Moreover, injection of OXT also reversed GRS-induced increase of TrkB in PVN of PPD rats. All those data suggest that OXT plays an antidepressant role by, at least in part, modulating HPA axis via TrkB in PVN of PPD rats.
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DOI：
10.1176/ajp.152.6.843
发表时间：
1995-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
M. Keller;D. Klein;R. Hirschfeld;J. Kocsis;J. P. Mccullough;I. Miller;M. First;Charles P. Holzer;G. Keitner;D. Marin;T. Shea
通讯作者：
M. Keller;D. Klein;R. Hirschfeld;J. Kocsis;J. P. Mccullough;I. Miller;M. First;Charles P. Holzer;G. Keitner;D. Marin;T. Shea
影响因子：
3.4
作者：
P. Willner;A. Towell;D. Sampson;S. Sophokleous;R. Muscat
通讯作者：
P. Willner;A. Towell;D. Sampson;S. Sophokleous;R. Muscat
影响因子：
2.7
作者：
Arbabi, Leila;Baharuldin, Mohamad. Taufik Hidayat;Muhammad, Sani Ismaila
通讯作者：
Muhammad, Sani Ismaila
影响因子：
4.8
作者：
Daskalakis NP;De Kloet ER;Yehuda R;Malaspina D;Kranz TM
通讯作者：
Kranz TM
影响因子：
5
作者：
PORSOLT, RD;ANTON, G;JALFRE, M
通讯作者：
JALFRE, M