Simulation study of a novel small animal FLASH irradiator (SAFI) with integrated inverse-geometry CT based on circularly distributed kV X-ray sources.
Simulation study of a novel small animal FLASH irradiator (SAFI) with integrated inverse-geometry CT based on circularly distributed kV X-ray sources.
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DOI：
10.1038/s41598-023-47421-0
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发表时间：
2023-11-17
影响因子：
4.6
通讯作者：
Zhang, Tiezhi
中科院分区：
文献类型：
--
作者：
Tan, Yuewen;Zhou, Shuang;Haefner, Jonathan;Chen, Qinghao;Mazur, Thomas R.;Darafsheh, Arash;Zhang, Tiezhi
超高剂量率（UHDR）放射治疗（RT）或FLASH-RT可以潜在地降低正常组织毒性。FLASH-RT的临床前研究需要一种能够提供与临床RT治疗类似的FLASH-RT治疗的小动物照射器。设计并模拟了一种基于分布式x射线源技术的小动物FLASH辐照器（SAFI）。SAFI系统包括一个分布x射线源，其51个焦点均匀分布在直径20厘米的环上，可用于FLASH-RT和机载微ct成像。采用蒙特卡罗模拟方法估计了SAFI治疗光束的剂量学特性。基于有限元分析（FEA）估算了受钨靶功率密度限制的最大剂量率。受钨靶线焦斑功率密度限制，最大直流电子束电流密度为2.6 mA/mm2。在160 kVp下，51个焦点，每个焦点的尺寸为mm2，阳极角为10°，可以在圆柱形水影的中心产生高达120 Gy/s的最大直流辐射。通过数值模拟，我们进一步演示了FLASH-RT的正向和反向规划，以及圆形源阵列成像的逆几何微型ct。
Ultra-high dose rate (UHDR) radiotherapy (RT) or FLASH-RT can potentially reduce normal tissue toxicity. A small animal irradiator that can deliver FLASH-RT treatments similar to clinical RT treatments is needed for pre-clinical studies of FLASH-RT. We designed and simulated a novel small animal FLASH irradiator (SAFI) based on distributed x-ray source technology. The SAFI system comprises a distributed x-ray source with 51 focal spots equally distributed on a 20 cm diameter ring, which are used for both FLASH-RT and onboard micro-CT imaging. Monte Carlo simulation was performed to estimate the dosimetric characteristics of the SAFI treatment beams. The maximum dose rate, which is limited by the power density of the tungsten target, was estimated based on finite-element analysis (FEA). The maximum DC electron beam current density is 2.6 mA/mm2, limited by the tungsten target's linear focal spot power density. At 160 kVp, 51 focal spots, each with a dimension of mm2 and 10° anode angle, can produce up to 120 Gy/s maximum DC irradiation at the center of a cylindrical water phantom. We further demonstrate forward and inverse FLASH-RT planning, as well as inverse-geometry micro-CT with circular source array imaging via numerical simulations.
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影响因子：
3.8
作者：
Chen Q;Zhou S;Tan Y;Hao Y;Zhang Z;Mazur T;Zhang T
通讯作者：
Zhang T
DOI：
10.1109/trpms.2021.3091406
发表时间：
2022-03
影响因子：
4.4
作者：
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作者：
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通讯作者：
Vozenin, Marie-Catherine
影响因子：
3.8
作者：
Darafsheh, Arash;Hao, Yao;Zhao, Tianyu
通讯作者：
Zhao, Tianyu