Protective cranial implant caps for macaques.
Protective cranial implant caps for macaques.
复制标题
DOI：
10.1016/j.jneumeth.2020.108992
复制
发表时间：
2021-01-15
影响因子：
3
通讯作者：
Mitchell AS
中科院分区：
文献类型：
--
作者：
Perry BAL;Mason S;Nacef J;Waddle A;Hynes B;Bergmann C;Schmid MC;Petkov CI;Thiele A;Mitchell AS
一种非人类灵长类动物保护性头帽，可促进颅骨植入后的伤口愈合。头帽的使用减少了伤口裂开和重新缝合手术伤口的需要。头帽很容易调节，以覆盖大多数灵长类动物的颅骨植入物。头帽有助于神经科学中的灵长类动物颅骨植入物伤口管理。猕猴的神经科学研究可能需要颅骨植入物来稳定头部或出于科学目的进入大脑。在非人类灵长类动物中，促进颅骨植入手术后愈合的伤口管理可能很困难，因为不一定能够覆盖伤口边缘。在这里，我们开发了一种易于修改的头帽，可在颅骨植入手术后保护缝合的皮肤边缘，并有助于伤口愈合。保护性头帽的开发是为了应对猴子在植入物周围缝合的皮肤边缘采摘，使愈合复杂化。使用者友好型保护帽由Klarity-R ™片材（3.2 mm厚，穿孔率为36%或42%）制成，术后固定在植入物上。一旦固定，当猴子仍然处于麻醉状态时，塑料薄膜就围绕植入物成型。保护性头帽限制猴子的手指接近其伤口边缘，同时允许空气流通以促进伤口愈合。在英国的两个灵长类动物设施中，保护性头帽促进了伤口愈合。在未戴头帽的猴中，约30%的病例需要重新戴帽。相比之下，没有一只戴着头帽的猴子需要重新戴上帽子。戴着头帽的猴子也减少了处方抗生素和止痛药的天数。这种定制的、易于适应的保护性头帽支持术后伤口愈合，并提高了参与神经科学研究的猴子的福利。
A non-human primate protective head cap that promotes wound healing after cranial implants. Use of the head cap reduced wound dehiscence and the need to re-suture surgical wounds. The head cap is easily adjustable to cover most primate cranial implants. The head cap facilitates primate cranial implant wound management in neuroscience. Neuroscience studies with macaque monkeys may require cranial implants to stabilize the head or gain access to the brain for scientific purposes. Wound management that promotes healing after the cranial implant surgery in non-human primates can be difficult as it is not necessarily possible to cover the wound margins. Here, we developed an easily modifiable head cap that protects the sutured skin margins after cranial implant surgery and contributes to wound healing. The protective head cap was developed in response to monkeys picking at sutured skin margins around an implant, complicating healing. The user-friendly protective cap, made from Klarity- R™ Sheet (3.2 mm thick with 36 % or 42 % perforation) is affixed to the implant post-surgically. Once secured and while the monkey is still anesthetized, the plastic sheeting is molded around the implant. The protective head cap restricts the monkey’s finger access to its’ wound margins while allowing air to circulate to promote wound healing. Across two UK primate facilities, the protective head cap promoted wound healing. In monkeys that did not wear the head cap, re-suturing was necessary in ∼30 % of cases. In contrast, none of the monkeys that wore the head cap required re-suturing. The monkeys wearing the head cap also had reduced numbers of days of prescribed antibiotics and analgesia. This bespoken, easily adaptable, protective head cap supports postoperative wound healing, and enhances the welfare of monkeys involved in neuroscience research.
登录
查看更多内容
影响因子：
3
作者：
Pigarev, I. N.;Saalmann, Y. B.;Vidyasagar, T. R.
通讯作者：
Vidyasagar, T. R.
影响因子：
3
作者：
Thiele, A.;Delicato, L. S.;Roberts, M. J.;Gieselmann, M. A.
通讯作者：
Gieselmann, M. A.
影响因子：
2.6
作者：
Eley, K. A.;Mcintyre, A. G.;Golding, S. J.
通讯作者：
Golding, S. J.
影响因子：
3
作者：
Ortiz-Rios M;Haag M;Balezeau F;Frey S;Thiele A;Murphy K;Schmid MC
通讯作者：
Schmid MC
影响因子：
3
作者：
Mason, Stuart;Premereur, Elsie;Mitchell, Anna S.
通讯作者：
Mitchell, Anna S.