Acute, but not longer-term, exposure to environmental enrichment attenuates Pavlovian cue-evoked conditioned approach and Fos expression in the prefrontal cortex in mice.
Acute, but not longer-term, exposure to environmental enrichment attenuates Pavlovian cue-evoked conditioned approach and Fos expression in the prefrontal cortex in mice.
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DOI：
10.1111/ejn.15146
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Koya E
中科院分区：
文献类型：
--
作者：
Margetts-Smith G;Macnaghten AI;Brebner LS;Ziminski JJ;Sieburg MC;Grimm JW;Crombag HS;Koya E
暴露于丰富的环境可以改变动机相关刺激的影响。例如，之前在大鼠中的研究发现，即使是短暂的急性（约1天），但不是慢性的，暴露于环境富集（EE）的住房也会减弱条件强化设置中蔗糖相关线索的工具杠杆按压。此外，急性EE降低皮质类固醇活性，如通过神经元活性标记物“Fos”表达的降低所测量的。目前，尚不清楚急性EE是否也会减少非偶然或“强迫”暴露于蔗糖提示（更类似于日常生活中遇到的提示暴露）引起的蔗糖寻求和皮质醇活动。因此，我们测量了急性/间歇性（1天或6天的EE之前的测试日）与慢性（EE在整个条件持续到测试日）EE的巴甫洛夫蔗糖线索的能力，引发蔗糖寻求（条件的方法）和Fos的表达在内侧前额叶皮层（mPFC），眶额皮层（OFC），和神经核（NAc）的小鼠。一天，但不是6天或慢性EE，减少蔗糖寻求和Fos在背侧mPFC的深层。相比之下，1天，6天，慢性EE都减少了Fos在OFC的浅层。没有EE操作调制NAc Fos表达。我们揭示了EE如何通过减少前额叶皮层脑区的活动来减少对蔗糖线索的行为反应。我们的工作进一步证明了EE的鲁棒性，它能够调节各种形式的跨物种的奖励寻求。
Exposure to environmental enrichment can modify the impact of motivationally relevant stimuli. For instance, previous studies in rats have found that even a brief, acute (~1 day), but not chronic, exposure to environmentally enriched (EE) housing attenuates instrumental lever pressing for sucrose-associated cues in a conditioned reinforcement setup. Moreover, acute EE reduces corticoaccumbens activity, as measured by decreases in expression of the neuronal activity marker “Fos.” Currently, it is not known whether acute EE also reduces sucrose seeking and corticoaccumbens activity elicited by non-contingent or “forced” exposure to sucrose cues, which more closely resembles cue exposure encountered in daily life. We therefore measured the effects of acute/intermittent (1 day or 6 day of EE prior to test day) versus chronic (EE throughout conditioning lasting until test day) EE on the ability of a Pavlovian sucrose cue to elicit sucrose seeking (conditioned approach) and Fos expression in the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), and nucleus accumbens (NAc) in mice. One day, but not 6 day or chronic EE, reduced sucrose seeking and Fos in the deep layers of the dorsal mPFC. By contrast, 1 day, 6 day, and chronic EE all reduced Fos in the shallow layers of the OFC. None of the EE manipulations modulated NAc Fos expression. We reveal how EE reduces behavioral reactivity to sucrose cues by reducing activity in select prefrontal cortical brain areas. Our work further demonstrates the robustness of EE in its ability to modulate various forms of reward-seeking across species.
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影响因子：
1.6
作者：
Grimm JW;Osincup D;Wells B;Manaois M;Fyall A;Buse C;Harkness JH
通讯作者：
Harkness JH
影响因子：
3.1
作者：
Grimm JW;Barnes JL;Koerber J;Glueck E;Ginder D;Hyde J;Eaton L
通讯作者：
Eaton L
影响因子：
2.2
作者：
Hammerslag, Lindsey R.;Gulley, Joshua M.
通讯作者：
Gulley, Joshua M.
影响因子：
5.3
作者：
Fuchs, RA;Evans, KA;See, RE
通讯作者：
See, RE
DOI：
10.1038/nrn3597
发表时间：
2013-11
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Cruz FC;Koya E;Guez-Barber DH;Bossert JM;Lupica CR;Shaham Y;Hope BT
通讯作者：
Hope BT