Ambient air pollution and atherosclerosis in Los Angeles.
Ambient air pollution and atherosclerosis in Los Angeles.
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DOI：
10.1289/ehp.7523
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发表时间：
2005-02
影响因子：
10.4
通讯作者：
Hodis HN
中科院分区：
文献类型：
--
作者：
Künzli N;Jerrett M;Mack WJ;Beckerman B;LaBree L;Gilliland F;Thomas D;Peters J;Hodis HN
已发现长期暴露于环境空气污染与心血管疾病发病率和死亡率之间存在关联。空气污染对导致许多心血管疾病的动脉粥样硬化的影响尚未得到研究。动物数据表明，周围的颗粒物（PM）可能有助于动脉粥样硬化。我们使用来自两项临床试验的798名参与者的数据，研究动脉粥样硬化与长期暴露于空气动力学直径（PM2.5）高达2.5 μ m的环境PM之间的关系。基线数据包括颈动脉内膜中层厚度（CIMT）的评估，这是亚临床动脉粥样硬化的一个指标。我们对受试者的居住区进行了地理编码，以分配环境PM2.5的年平均浓度。暴露值分配从PM2.5表面来自地质统计模型。单独分配的年平均PM2.5浓度范围为5.2至26.9微克/立方米（平均值为20.3）。对于10 μ g/m3 PM2.5的横截面暴露对比，CIMT增加了5.9%（95%置信区间，1 - 11%）。年龄校正降低了系数，但协变量的进一步校正表明稳健估计值在3.9 - 4.3%范围内（p值，0.05 - 0.1）。在老年受试者（≥ 60岁）、女性、从不吸烟者和基线时报告接受降脂治疗的受试者中，PM2.5和CIMT的相关性更大，其中≥ 60岁女性的相关性最强（15.7%，5.7 - 26.6%）。这些结果代表了动脉粥样硬化和环境空气污染之间的关联的第一个流行病学证据。鉴于心血管疾病作为死亡原因的主导作用以及大量人群暴露于环境PM2.5，这些发现可能很重要，需要进一步确认。
Associations have been found between long-term exposure to ambient air pollution and cardiovascular morbidity and mortality. The contribution of air pollution to atherosclerosis that underlies many cardiovascular diseases has not been investigated. Animal data suggest that ambient particulate matter (PM) may contribute to atherogenesis. We used data on 798 participants from two clinical trials to investigate the association between atherosclerosis and long-term exposure to ambient PM up to 2.5 μm in aerodynamic diameter (PM2.5). Baseline data included assessment of the carotid intima-media thickness (CIMT), a measure of subclinical atherosclerosis. We geocoded subjects’ residential areas to assign annual mean concentrations of ambient PM2.5. Exposure values were assigned from a PM2.5 surface derived from a geostatistical model. Individually assigned annual mean PM2.5 concentrations ranged from 5.2 to 26.9 μg/m3 (mean, 20.3). For a cross-sectional exposure contrast of 10 μg/m3 PM2.5, CIMT increased by 5.9% (95% confidence interval, 1–11%). Adjustment for age reduced the coefficients, but further adjustment for covariates indicated robust estimates in the range of 3.9–4.3% (p-values, 0.05–0.1). Among older subjects (≥60 years of age), women, never smokers, and those reporting lipid-lowering treatment at baseline, the associations of PM2.5 and CIMT were larger with the strongest associations in women ≥60 years of age (15.7%, 5.7–26.6%). These results represent the first epidemiologic evidence of an association between atherosclerosis and ambient air pollution. Given the leading role of cardiovascular disease as a cause of death and the large populations exposed to ambient PM2.5, these findings may be important and need further confirmation.
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DOI：
10.1164/rccm.2111021
发表时间：
2002-07-01
影响因子：
24.7
作者：
Gauderman, WJ;Gilliland, GF;Peters, JM
通讯作者：
Peters, JM
DOI：
10.1164/ajrccm.155.1.9001300
发表时间：
1997-01-01
影响因子：
24.7
作者：
AckermannLiebrich, U;Leuenberger, P;Zemp, E
通讯作者：
Zemp, E
影响因子：
37.8
作者：
Hodis, HN;Mack, WJ;Azen, SP
通讯作者：
Azen, SP
DOI：
10.1038/sj.jea.7500244
发表时间：
2002-11-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Leech, JA;Nelson, WC;Raizenne, ME
通讯作者：
Raizenne, ME
DOI：
10.1165/ajrcmb.27.1.4787
发表时间：
2002-07-01
影响因子：
6.4
作者：
Fujii, T;Hayashi, S;van Eeden, SF
通讯作者：
van Eeden, SF