Seasonal incidence of medically attended respiratory syncytial virus infection in a community cohort of adults ≥50 years old.
Seasonal incidence of medically attended respiratory syncytial virus infection in a community cohort of adults ≥50 years old.
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DOI：
10.1371/journal.pone.0102586
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Belongia EA
中科院分区：
文献类型：
--
作者：
McClure DL;Kieke BA;Sundaram ME;Simpson MD;Meece JK;Sifakis F;Gasser RA Jr;Belongia EA
呼吸道合胞病毒（RSV）的诊断检测在成人中没有常规进行。我们估计了在四个流感季节（2006-07至2009-10），在一个≥50岁的社区成人队列中接受医学治疗的RSV季节性发病率。前瞻性地纳入了寻求急性呼吸道疾病（ARI）治疗的患者，并通过多重RT-PCR检测RSV。入组患者的结果用于估计未入组的ARI患者的预计病例。住院RSV的季节性发病率为实际病例和预测病例之和除以社区队列分母。由于每个入组期不包括整个RSV季节，因此对发病率估计值进行了调整，以考虑在研究入组期外发生的RSV在全州范围内的比例。每个季节有16,088至17,694名成年人，所有4个季节有164例RSV病例。住院RSV的总体季节性发病率为每10,000人154例（95% CI, 132-180）；发病率最高的是2007-08年（179），最低的是2006-07年（110）。在50-59岁、60-69岁和≥70岁的人群中，RSV发病率分别为124 （95% CI, 99-156）、147 （95% CI, 110-196）和199 （95% CI, 153-258）。经医疗护理的呼吸道合胞病毒的发病率随年龄增长而增加，并且在四个季节中相似。
Diagnostic testing for respiratory syncytial virus (RSV) is not routinely performed in adults. We estimated medically attended RSV seasonal incidence in a community cohort of adults ≥50 years old during four influenza seasons (2006–07 through 2009–10). Patients seeking care for acute respiratory illness (ARI) were prospectively enrolled and tested for RSV by multiplex RT-PCR. Results from enrolled patients were used to estimate projected cases among non-enrolled patients with ARI. The seasonal incidence of medically attended RSV was the sum of actual and projected cases divided by the community cohort denominator. Since each enrollment period did not include the entire RSV season, incidence estimates were adjusted to account for the statewide proportion of RSV occurring outside the study enrollment period. There were 16,088 to 17,694 adults in the cohort each season and 164 RSV cases in all 4 seasons. The overall seasonal incidence of medically attended RSV was 154 episodes (95% CI, 132–180) per 10,000 persons; the incidence was highest in 2007–08 (179) and lowest in 2006–07 (110). Among persons 50–59, 60–69, and ≥70 years old, RSV incidence was 124 (95% CI, 99–156), 147 (95% CI, 110–196), and 199 (95% CI, 153–258), respectively. The incidence of medically attended RSV increased with age and was similar during four seasons.
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