Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing.
Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing.
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北京市急诊科成年患者呼吸道病毒感染的病原学及临床特征
DOI：
10.1371/journal.pone.0032174
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Tan W
中科院分区：
文献类型：
--
作者：
Yu X;Lu R;Wang Z;Zhu N;Wang W;Julian D;Chris B;Lu J;Tan W
背景 急性呼吸道感染（ARTIs）是一个严重的全球健康负担。迄今为止，很少有报告涉及到急诊室 (ED) 就诊的患有 ARTI 的成人中呼吸道病毒 (RV) 的流行情况。因此，呼吸道病毒感染对此类患者的潜在影响仍不清楚。方法/主要发现 为了确定在北京急诊科就诊的 ARTI 成人患者中常见和最近发现的呼吸道病毒的流行病学和临床特征，我们从 2010 年 5 月到 2011 年 4 月进行了一项连续一年的研究。通过对常见呼吸道病毒（包括流感病毒 (Flu)）进行多重逆转录聚合酶链反应 (RT-PCR) 检测，对 416 名 ARTI 患者的鼻咽拭子样本中的 13 种呼吸道病毒进行了检查。 A、B 和腺病毒 (ADV)、小核糖核酸病毒 (PIC)、呼吸道合胞病毒 (RSV)、副流感病毒 (PIV) 1-3，结合实时 RT-PCR 检测人类偏肺病毒 (HMPV) 和人类冠状病毒（HCoV、-OC43、-229E、-NL63 和 -HKU1）。 52.88%（220/416）的患者样本中检测到病毒病原体，7.21%（30/416）的患者检测出一种以上病毒呈阳性。 PIC (17.79%) 是检测到的主要病原体，其次是 FluA (16.11%)、HCoV (11.78%) 和 ADV (11.30%)。还检测到 HMPV、PIV 和 FluB (<3%)，但未检测到 RSV。我们的报告与之前的报告相比，检测到的总流行率和主要病毒感染存在显着差异。 HCoV-229E (12/39, 30.76%)、PIC (22/74, 29.73%)、ADV (12/47, 25.53%) 和 FluA (15/67, 22.39%) 的合并感染率较高。不同的临床症状模式与不同的呼吸道病毒有关。结论 中国急诊科就诊的 ARTI 成人患者的右心室受累模式与之前报道的不同。这里报告的病毒（PIC、FluA、HCoV 和 ADV）的高流行强烈强调需要开发针对这些病毒的安全有效的治疗方法。
Background Acute respiratory tract infections (ARTIs) represent a serious global health burden. To date, few reports have addressed the prevalence of respiratory viruses (RVs) in adults with ARTIs attending an emergency department (ED). Therefore, the potential impact of respiratory virus infections on such patients remains unknown. Methodology/Principal Findings To determine the epidemiological and clinical profiles of common and recently discovered respiratory viruses in adults with ARTIs attending an ED in Beijing, a 1-year consecutive study was conducted from May, 2010, to April, 2011. Nose and throat swab samples from 416 ARTI patients were checked for 13 respiratory viruses using multiple reverse transcription polymerase chain reaction(RT-PCR) assays for common respiratory viruses, including influenza viruses (Flu) A, B, and adenoviruses (ADVs), picornaviruses (PICs), respiratory syncytial virus (RSV), parainfluenza viruses (PIVs) 1–3, combined with real-time RT-PCR for human metapneumovirus (HMPV) and human coronaviruses (HCoVs, -OC43, -229E, -NL63, and -HKU1). Viral pathogens were detected in 52.88% (220/416) of patient samples, and 7.21% (30/416) of patients tested positive for more than one virus. PICs (17.79%) were the dominant agents detected, followed by FluA (16.11%), HCoVs (11.78%), and ADV (11.30%). HMPV, PIVs, and FluB were also detected (<3%), but not RSV. The total prevalence and the dominant virus infections detected differed significantly between ours and a previous report. Co-infection rates were high for HCoV-229E (12/39, 30.76%), PIC (22/74, 29.73%), ADV (12/47, 25.53%) and FluA (15/67, 22.39%). Different patterns of clinical symptoms were associated with different respiratory viruses. Conclusions The pattern of RV involvement in adults with ARTIs attending an ED in China differs from that previously reported. The high prevalence of viruses (PIC, FluA, HCoVs and ADV) reported here strongly highlight the need for the development of safe and effective therapeutic approaches for these viruses.
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影响因子：
82.9
作者：
van den Hoogen BG;de Jong JC;Groen J;Kuiken T;de Groot R;Fouchier RA;Osterhaus AD
通讯作者：
Osterhaus AD
DOI：
10.1111/j.1469-0691.2009.02746.x
发表时间：
2009-12
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Ren L;Gonzalez R;Wang Z;Xiang Z;Wang Y;Zhou H;Li J;Xiao Y;Yang Q;Zhang J;Chen L;Wang W;Li Y;Li T;Meng X;Zhang Y;Vernet G;Paranhos-Baccalà G;Chen J;Jin Q;Wang J
通讯作者：
Wang J
DOI：
10.1016/j.jcv.2009.03.008
发表时间：
2009-05
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Greer RM;McErlean P;Arden KE;Faux CE;Nitsche A;Lambert SB;Nissen MD;Sloots TP;Mackay IM
通讯作者：
Mackay IM
影响因子：
5.4
作者：
Woo, PCY;Lau, SKP;Yuen, KY
通讯作者：
Yuen, KY
影响因子：
9.4
作者：
Maertzdorf, J;Wang, CK;Fouchier, RAM
通讯作者：
Fouchier, RAM