Target genes for virulence assessment of Escherichia coli isolates from water, food and the environment.
Target genes for virulence assessment of Escherichia coli isolates from water, food and the environment.
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用于从水、食物和环境中分离的大肠杆菌毒力评估的目标基因。
DOI：
10.1111/j.1574-6976.2000.tb00535.x
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发表时间：
2000
影响因子：
11.3
通讯作者：
Joachim Frey
中科院分区：
文献类型：
--
作者：
Peter Kuhnert;Patrick Boerlin;Joachim Frey
广泛分布的大肠杆菌包括多种不同类型，从引起世界范围内严重疾病爆发的高致病性菌株到无毒力分离株，无毒力分离株是正常肠道植物群的一部分，或者是充分表征的安全实验室菌株。对E.大肠杆菌的致病性主要由粘附素、侵袭素、毒素和荚膜等特异性毒力因子决定。它们通常在染色体（“致病岛”）、大质粒或质粒上以大的遗传区块组织，并且可以在菌株之间水平传播。本文综述了大肠杆菌的毒力特性及其致病潜力。大肠杆菌菌株和现有的方法来评估的毒力。大肠杆菌分离株。我们还重点介绍了最近开发的一种基于宽范围检测系统的E。大肠杆菌特异性毒力基因，使确定大肠杆菌的潜在致病性及其性质成为可能。大肠杆菌菌株。这为确定E.大肠杆菌菌株在医学诊断中的应用，以评估大肠杆菌的毒力和健康风险。大肠杆菌污染水，食品和环境，并研究潜在的水库的毒力基因，可能有助于出现新形式的致病性大肠杆菌。杆菌
The widespread species Escherichia coli includes a broad variety of different types, ranging from highly pathogenic strains causing worldwide outbreaks of severe disease to avirulent isolates which are part of the normal intestinal flora or which are well characterized and safe laboratory strains. The pathogenicity of a given E. coli strain is mainly determined by specific virulence factors which include adhesins, invasins, toxins and capsule. They are often organized in large genetic blocks either on the chromosome ('pathogenicity islands'), on large plasmids or on phages and can be transmitted horizontally between strains. In this review we summarize the current knowledge of the virulence attributes which determine the pathogenic potential of E. coli strains and the methodology available to assess the virulence of E. coli isolates. We also focus on a recently developed procedure based on a broad-range detection system for E. coli-specific virulence genes that makes it possible to determine the potential pathogenicity and its nature in E. coli strains from various sources. This makes it possible to determine the pathotype of E. coli strains in medical diagnostics, to assess the virulence and health risks of E. coli contaminating water, food and the environment and to study potential reservoirs of virulence genes which might contribute to the emergence of new forms of pathogenic E. coli.
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DOI：
--
发表时间：
1982-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
E. Spicer;J. A. Noble
通讯作者：
E. Spicer;J. A. Noble
DOI：
10.1073/pnas.87.20.7839
发表时间：
1990-10-01
影响因子：
11.1
作者：
JERSE, AE;YU, J;KAPER, JB
通讯作者：
KAPER, JB
影响因子：
56.9
作者：
GIRON, JA;HO, ASY;SCHOOLNIK, GK
通讯作者：
SCHOOLNIK, GK
影响因子：
15.9
作者：
Donnenberg, MS;Kaper, JB;Finlay, BB
通讯作者：
Finlay, BB
DOI：
10.1073/pnas.92.5.1664
发表时间：
1995-02-28
影响因子：
11.1
作者：
MCDANIEL, TK;JARVIS, KG;KAPER, JB
通讯作者：
KAPER, JB