Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence.
Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence.
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DOI：
10.1038/sj.bjc.6601531
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发表时间：
2004-01-26
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
粘蛋白型O-连接蛋白的初始糖基化由UDP-GalNAc之一催化：多肽N-乙酰基-半乳糖胺转移酶-3（GalNAc-T3）。O-糖基化在肿瘤中细胞粘附分子的结合、细胞分化、侵袭和转移中是重要的。本研究采用免疫组化方法检测GalNAc-T3在肺腺癌组织中的表达，探讨GalNAc-T3表达水平与肺腺癌全切除患者预后及复发的关系。148例肺腺癌患者中79例（53.4%）的肿瘤细胞胞浆中检测到GalNAc-T3的低表达。GalNAc-T3的低表达与肿瘤分化程度低（P<0.0001）、病理分期差（P<0.0001）、淋巴结转移（P<0.0001）和肿瘤复发（P=0.016）有关。单因素和多因素分析显示，GalNAc-T3低表达肺癌患者的预后差于GalNAc-T3高表达肺癌患者（总生存期分别为P<0.0001和P=0.011）。多因素分析显示，GalNAc-T3低表达是预测I期肺腺癌预后不良和早期复发的独立因素（P=0.006，rr=2.87和P=0.019，rr=3.05）。GalNAc-T3的低表达可能是预测完全切除肺癌患者，特别是I期患者预后不良和早期复发的有用指标。
Initial glycosylation of mucin-type O-linked protein is catalysed by one of the UDP-GalNAc: polypeptide N-acetyl-galactosaminyl transferase-3 (GalNAc-T3). O-glycosylation is important in the binding of cell adhesion molecules, cell differentiation, invasion, and metastasis in tumours. This study was designed to detect GalNAc-T3 expression in lung adenocarcinoma by using immunohistochemical staining, and to evaluate the relationship between the GalNAc-T3 expression level and prognosis and recurrence in completely resected lung adenocarcinoma patients. A low expression of GalNAc-T3 was detected in the cytoplasm of tumour cells in 79 of 148 patients (53.4%) with lung adenocarcinoma. The low expression of GalNAc-T3 was associated with poorly differentiated tumour (P<0.0001), poor pathologic stage (P<0.0001), lymph node metastasis (P<0.0001), and tumour recurrence (P=0.016). The lung carcinoma patients with low GalNAc-T3 expression had a poorer prognosis than those with high GalNAc-T3 expression, using both univariate and multivariate analyses (overall survival: P<0.0001 and P=0.011, respectively). In addition, multivariate analysis of the clinicopathological characteristics of stage I lung adenocarcinoma indicated that the low expression of GalNAc-T3 was a significant independent factor for predicting poor prognosis and early recurrence (P=0.006, rr=2.87 and P=0.019, rr=3.05, respectively). The low expression of GalNAc-T3 may be a useful marker for predicting poor prognosis and early recurrence in completely resected lung carcinoma patients, particularly patients with stage I diseases.
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影响因子：
56.9
作者：
PHILLIPS, ML;NUDELMAN, E;PAULSON, JC
通讯作者：
PAULSON, JC
影响因子：
3.5
作者：
Bennett, EP;Hassan, H;Clausen, H
通讯作者：
Clausen, H
影响因子：
4.8
作者：
Bennett, EP;Hassan, H;Clausen, H
通讯作者：
Clausen, H
影响因子：
8.8
作者：
Peto R;Pike MC;Armitage P;Breslow NE;Cox DR;Howard SV;Mantel N;McPherson K;Peto J;Smith PG
通讯作者：
Smith PG
影响因子：
29.4
作者：
NAKAMORI, S;OTA, DM;IRIMURA, T
通讯作者：
IRIMURA, T