Going local: technologies for exploring bacterial microenvironments.

Going local: technologies for exploring bacterial microenvironments.
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DOI:
10.1038/nrmicro3010
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发表时间:
2013-05
期刊:
Nature reviews. Microbiology
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其他
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微生物主导社会生活,并利用协调的化学和物理相互作用建立复杂的群落。对这些相互作用的机械学见解揭示了协调微生物行为的非常复杂的系统,但对这些相互作用如何在自然界中发现的空间组织的社区中进行知之甚少。本综述介绍了可用于空间组织小微生物群落的技术和表征这些群落周围化学环境的分析方法。总之,这些互补的技术提供了新的见解,空间组织对微生物行为和微生物群落内表型异质性的发展的影响。
Microorganisms lead social lives and use coordinated chemical and physical interactions to establish complex communities. Mechanistic insights into these interactions have revealed that there are remarkably intricate systems for coordinating microbial behaviour, but little is known about how these interactions proceed in the spatially organized communities that are found in nature. This Review describes the technologies available for spatially organizing small microbial communities and the analytical methods for characterizing the chemical environment surrounding these communities. Together, these complementary technologies have provided novel insights into the impact of spatial organization on both microbial behaviour and the development of phenotypic heterogeneity within microbial communities.
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