Chemical databases for environmental health and clinical research.

Chemical databases for environmental health and clinical research.
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DOI:
10.1016/j.toxlet.2008.10.003
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发表时间:
2009-04-10
期刊:
影响因子:
3.5
通讯作者:
Mattingly, Carolyn J.
Mattingly, Carolyn J.
中科院分区:
医学3区
文献类型:
--
作者:
Mattingly, Carolyn J.

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越来越多的公开生物数据库反映了管理和评估生物学、临床和计算研究中丰富和复杂数据的不断发展的需求。目前,公共领域有1000多个生物学相关数据库,内容各异,获取和呈现数据的方法也多种多样。本综述总结了旨在加强对化学品及其生物作用的了解的先进数据库和其他资源的相对较小的利基。审查的数据库包括一个强调环境化学品的数据库和9个强调药物和小分子的数据库。这些数据库及其相关资源正在逐步加强不断扩大的毒理基因组学研究领域,为不断增加的环境化学,药物和小分子数据集的荟萃分析提供手动和计算管理的数据集和高度复杂的工具的集中来源。
The increasing number of publicly available biological databases reflects the evolving need for managing and evaluating abundant and complex data in biological, clinical and computational research. Currently there are over 1000 biologically relevant databases in the public domain with varied content and diverse approaches to capturing and presenting data. This review summarizes the comparatively small niche of sophisticated databases and other resources that aim to enhance understanding of chemicals and their biological actions. The databases reviewed include one that emphasizes environmental chemicals and 9 that emphasize drugs and small molecules. These databases and their associated resources are incrementally strengthening the expanding field of toxicogenomics-based research by providing centralized sources of manually and computationally curated datasets and highly sophisticated tools for the meta-analysis of continually increasing environmental chemical, drug and small molecule datasets.
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