Acquisition and establishment of the oral microbiota.
Acquisition and establishment of the oral microbiota.
复制标题
口腔微生物群的获取和建立。
DOI：
10.1111/prd.12366
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发表时间：
2021-06
影响因子：
18.6
通讯作者：
Zaura E
中科院分区：
文献类型：
--
作者：
Kaan AMM;Kahharova D;Zaura E
口腔微生物群的获取和建立是一个动态的过程，涉及到与宿主及其环境密切和持续的相互作用。在本综述中，我们将按时间顺序讨论这一过程的各个阶段。我们从产前开始，解决以下问题：“胎儿在怀孕期间是否暴露于母体微生物群？”和“如果是这样，这种暴露的潜在作用是什么？”“我们对最近在怀孕期间胎盘中发现细菌DNA的报道进行了评论，并就产前微生物接触的潜在功能提供了当前的观点。”接下来，我们将讨论新生儿在出生过程中发生的生理适应，以及这一阶段对口腔微生物群获取的影响。真的仅仅是暴露于母体阴道微生物导致了阴道出生的婴儿和剖腹产出生的婴儿之间的差异吗？然后，我们回顾了出生后阶段，重点关注微生物的传播，口腔内生态位特异性，宿主行为和环境的影响，以及宿主遗传背景在塑造口腔微生物生态系统中的作用。我们讨论了从乳牙到恒牙以及青春期期间口腔微生物群的变化。我们也解决了有限的知识定植口腔由微生物以外的细菌成分。最后，我们确定了主要的悬而未决的问题，这些问题限制了我们对个体水平上健康微生物群的获取和建立的理解。
Acquisition and establishment of the oral microbiota occur in a dynamic process over various stages and involve close and continuous interactions with the host and its environment. In the present review, we discuss the stages of this process in chronological order. We start with the prenatal period and address the following questions: ‘Is the fetus exposed to maternal microbiota during pregnancy?’ and ‘If so, what is the potential role of this exposure?’ We comment on recent reports of finding bacterial DNA in placenta during pregnancies, and provide current views on the potential functions of prenatal microbial encounters. Next, we discuss the physiological adaptations that take place in the newborn during the birth process and the effect of this phase of life on the acquisition of the oral microbiota. Is it really just exposure to maternal vaginal microbes that results in the difference between vaginally and Cesarian section‐born infants? Then, we review the postnatal phase, in which we focus on transmission of microbes, the intraoral niche specificity, the effects of the host behavior and environment, as well as the role of genetic background of the host on shaping the oral microbial ecosystem. We discuss the changes in oral microbiota during the transition from deciduous to permanent dentition and during puberty. We also address the finite knowledge on colonization of the oral cavity by microbes other than the bacterial component. Finally, we identify the main outstanding questions that limit our understanding of the acquisition and establishment of a healthy microbiome at an individual level.
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影响因子：
2.9
作者：
Boustedt K;Roswall J;Dahlén G;Dahlgren J;Twetman S
通讯作者：
Twetman S
产生龋齿的细菌定植的时机：基于研究单卵双胞胎对的方法。
影响因子：
2.1
作者：
Bockmann MR;Harris AV;Bennett CN;Odeh R;Hughes TE;Townsend GC
通讯作者：
Townsend GC
影响因子：
4.2
作者：
Brailsford, SR;Sheehy, EC;Beighton, D
通讯作者：
Beighton, D
影响因子：
5.6
作者：
Abeles SR;Pride DT
通讯作者：
Pride DT
影响因子：
11
作者：
Abeles, Shira R.;Robles-Sikisaka, Refugio;Pride, David T.
通讯作者：
Pride, David T.