The Seminiferous Epithelial Cycle of Spermatogenesis: Role of Non-receptor Tyrosine Kinases.

The Seminiferous Epithelial Cycle of Spermatogenesis: Role of Non-receptor Tyrosine Kinases.
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精子发生的生精上皮周期:非受体酪氨酸激酶的作用。

DOI:
10.1007/978-3-030-77779-1_1
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发表时间:
2021
影响因子:
--
通讯作者:
Ni Ya
Ni Ya
中科院分区:
医学4区
文献类型:
--
作者:
Xiao Xiang;Zheng Dongwang;Liang Fei;Ying Shibo;Sun Peibei;Yu Jianmin;Ni Ya

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非受体酪氨酸激酶(NRTK)参与各种生物过程,包括细胞增殖、分化、存活和凋亡,以及细胞粘附和运动。NRTK在所有哺乳动物和不同的细胞类型中表达,在睾丸中的表达非常高。它们与质膜和动态亚细胞定位的关联是其活化和功能的关键参数。许多NRTK被发现存在于内体蛋白运输途径中,这提示了一种新的机制来调节哺乳动物睾丸中适时的连接重建,以促进精子形成和生殖细胞穿过生精上皮的运输。
Non-receptor tyrosine kinases (NRTKs) are implicated in various biological processes including cell proliferation, differentiation, survival, and apoptosis, as well as cell adhesion and movement. NRTKs are expressed in all mammals and in different cell types, with extraordinarily high expression in the testis. Their association with the plasma membrane and dynamic subcellular localization are crucial parameters in their activation and function. Many NRTKs are found in endosomal protein trafficking pathways, which suggests a novel mechanism to regulate the timely junction restructuring in the mammalian testis to facilitate spermiation and germ cell transport across the seminiferous epithelium.
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