Encoding of aversion by dopamine and the nucleus accumbens.
Encoding of aversion by dopamine and the nucleus accumbens.
复制标题
DOI：
10.3389/fnins.2012.00137
复制
发表时间：
2012
影响因子：
4.3
通讯作者：
Roitman MF
中科院分区：
文献类型：
--
作者：
McCutcheon JE;Ebner SR;Loriaux AL;Roitman MF
适应性动机行为需要快速区分有益和有害的刺激。这种歧视导致了适当的方法或排斥反应的产生，并使有机体能够最大限度地奖励和最大限度地减少惩罚。经典地说，伏隔核(NAC)及其多巴胺投射被认为是大脑奖赏回路的组成部分，即它们指导接近和消费行为，并构成积极强化的基础。这种以奖励为中心的框架忽略了关于这个系统在编码厌恶事件中所扮演的角色的重要证据。偏向奖赏的一个原因是难以设计让动物反复经历惩罚的实验；另一个原因是将对厌恶刺激的反应本身与当厌恶刺激终止时所经历的奖励/缓解分开的挑战。在这里，我们回顾了使用具有足够时间分辨率的技术来测量腹侧被盖区和NAC对厌恶刺激的反应的研究。我们还提出了新的发现，表明相同的刺激-口腔内输注蔗糖-对NAC壳多巴胺释放具有不同的影响，这取决于先前的经验。在这里，对于一些老鼠来说，蔗糖是通过在条件味觉厌恶范例中明确地将其与恶心配对而变得厌恶的。此后，注射蔗糖导致多巴胺的抑制，其程度和时间过程类似于口腔内注射苦奎宁溶液。这些结果是在多巴胺信号的区域差异和NAC壳内相多巴胺释放暂停的背景下讨论的。结合我们的数据，新出现的文献表明，不同时相多巴胺信号在厌恶和奖励中发挥着重要作用。
Adaptive motivated behavior requires rapid discrimination between beneficial and harmful stimuli. Such discrimination leads to the generation of either an approach or rejection response, as appropriate, and enables organisms to maximize reward and minimize punishment. Classically, the nucleus accumbens (NAc) and the dopamine projection to it are considered an integral part of the brain’s reward circuit, i.e., they direct approach and consumption behaviors and underlie positive reinforcement. This reward-centered framing ignores important evidence about the role of this system in encoding aversive events. One reason for bias toward reward is the difficulty in designing experiments in which animals repeatedly experience punishments; another is the challenge in dissociating the response to an aversive stimulus itself from the reward/relief experienced when an aversive stimulus is terminated. Here, we review studies that employ techniques with sufficient time resolution to measure responses in ventral tegmental area and NAc to aversive stimuli as they are delivered. We also present novel findings showing that the same stimulus – intra-oral infusion of sucrose – has differing effects on NAc shell dopamine release depending on the prior experience. Here, for some rats, sucrose was rendered aversive by explicitly pairing it with malaise in a conditioned taste aversion paradigm. Thereafter, sucrose infusions led to a suppression of dopamine with a similar magnitude and time course to intra-oral infusions of a bitter quinine solution. The results are discussed in the context of regional differences in dopamine signaling and the implications of a pause in phasic dopamine release within the NAc shell. Together with our data, the emerging literature suggests an important role for differential phasic dopamine signaling in aversion vs. reward.
登录
查看更多内容
影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
3.5
作者：
Beeler JA;Frazier CR;Zhuang X
通讯作者：
Zhuang X
影响因子：
4.7
作者：
Carlezon WA Jr;Thomas MJ
通讯作者：
Thomas MJ
影响因子：
2.5
作者：
BENABID, AL;JEAUGEY, L
通讯作者：
JEAUGEY, L