The functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma.
The functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma.
复制标题
DOI：
10.7150/ijbs.62767
复制
发表时间：
2021
影响因子：
9.2
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Qin S;Mao Y;Chen X;Xiao J;Qin Y;Zhao L
肝细胞癌（HCC）是全球癌症相关死亡的主要原因之一。肝细胞癌的死亡率和复发率很高，存活率很低。n6 -甲基腺苷（m6A）是真核rna中最丰富的修饰物，环状rna是一类由反剪接产生的环状非编码rna，它们在多种细胞过程中调节多种功能。虽然HCC的癌变过程是复杂的，但新出现的证据表明m6A修饰和circRNA在HCC的发生和进展中起着至关重要的作用。然而，控制HCC的潜在机制、它们的相互作用和临床意义尚未完全阐明。因此，本文通过阐述m6A修饰过程中三种不同的调控因子（“writer”、“eraser”和“reader”），阐明m6A修饰在HCC癌变中的生物学功能和分子机制。此外，我们剖析了circRNAs在HCC各种恶性行为中的功能作用，从而促进了HCC的发生、进展和复发。此外，我们通过揭示circRNA和m6A修饰协同作用对HCC进展的影响，证明了m6A修饰与circRNA之间的串扰和相互作用。最后，我们提出了m6A修饰物和环状rna作为HCC诊断、治疗和预后评估的诊断生物标志物和治疗靶点的临床潜力和意义。
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. HCC has high rates of death and recurrence, as well as very low survival rates. N6-methyladenosine (m6A) is the most abundant modification in eukaryotic RNAs, and circRNAs are a class of circular noncoding RNAs that are generated by back-splicing and they modulate multiple functions in a variety of cellular processes. Although the carcinogenesis of HCC is complex, emerging evidence has indicated that m6A modification and circRNA play vital roles in HCC development and progression. However, the underlying mechanisms governing HCC, their cross-talk, and clinical implications have not been fully elucidated. Therefore, in this paper, we elucidated the biological functions and molecular mechanisms of m6A modification in the carcinogenesis of HCC by illustrating three different regulatory factors ("writer", "eraser", and "reader") of the m6A modification process. Additionally, we dissected the functional roles of circRNAs in various malignant behaviors of HCC, thereby contributing to HCC initiation, progression and relapse. Furthermore, we demonstrated the cross-talk and interplay between m6A modification and circRNA by revealing the effects of the collaboration of circRNA and m6A modification on HCC progression. Finally, we proposed the clinical potential and implications of m6A modifiers and circRNAs as diagnostic biomarkers and therapeutic targets for HCC diagnosis, treatment and prognosis evaluation.
登录
查看更多内容
DOI：
10.1126/science.aad8711
发表时间：
2016-06-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gilbert WV;Bell TA;Schaening C
通讯作者：
Schaening C
影响因子：
50.3
作者：
Hanahan, Douglas;Coussens, Lisa M.
通讯作者：
Coussens, Lisa M.
circRNA生物合成的调控
影响因子：
4.1
作者：
Chen, Ling-Ling;Yang, Li
通讯作者：
Yang, Li
DOI：
10.1016/j.bbrc.2019.03.214
发表时间：
2019-06-11
影响因子：
3.1
作者：
Guo, Jianbo;Duan, He;Yuan, Lu
通讯作者：
Yuan, Lu
影响因子：
4.6
作者：
Abe N;Matsumoto K;Nishihara M;Nakano Y;Shibata A;Maruyama H;Shuto S;Matsuda A;Yoshida M;Ito Y;Abe H
通讯作者：
Abe H