Renally Excretable and Size-Tunable Silver Sulfide Nanoparticles for Dual-Energy Mammography or Computed Tomography.
Renally Excretable and Size-Tunable Silver Sulfide Nanoparticles for Dual-Energy Mammography or Computed Tomography.
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DOI：
10.1021/acs.chemmater.9b01750
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发表时间：
2019-10-08
期刊：
影响因子：
--
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Hsu JC;Cruz ED;Lau KC;Bouché M;Kim J;Maidment ADA;Cormode DP
显著的努力已经集中在开发肾可清除的纳米颗粒剂上，因为有效的肾清除对于最终的临床转化是重要的。硫化银纳米粒子（Ag 2S-NP）最近被确定为用于双能量乳腺X射线摄影、计算机断层扫描（CT）和荧光成像的造影剂以及用于药物递送和光热治疗的探针，具有良好的生物相容性。然而，迄今为止报道的大多数Ag 2S-NP不能经肾脏排泄，并且在体内观察到在网状内皮系统（RES）器官（即肝脏和脾脏）中蓄积和保留很长时间，这可能对其翻译的可能性产生负面影响。在本文中，我们提出了肾可清除的3.1 nm Ag 2S-NP，其中85%的注射剂量（ID）在静脉注射后24小时内排出，这是迄今为止报道的类似尺寸的纳米颗粒的最佳清除率之一（大多在ID的20-75%之间）。通过体内CT成像和生物分布分析表明这些纳米颗粒在小鼠中的尿排泄和低RES积累。总之，这些超小的Ag 2S-NP可以通过尿液有效地消除，并且具有用于各种生物医学应用的高转化潜力。
Significant effort has been focused on developing renally-clearable nanoparticle agents since efficient renal clearance is important for eventual clinical translation. Silver sulfide nanoparticles (Ag2S-NP) have recently been identified as contrast agents for dual energy mammography, computed tomography (CT) and fluorescence imaging and probes for drug delivery and photothermal therapy with good biocompatibility. However, most Ag2S-NP reported to date are not renally excretable and are observed in vivo to accumulate and remain in the reticuloendothelial system (RES) organs, i.e. liver and spleen, for a long time, which could negatively impact their likelihood for translation. Herein, we present renally-clearable, 3.1 nm Ag2S-NP with 85% of the injected dose (ID) being excreted within 24 hours of intravenous injection, which is amongst the best clearance of similarly sized nanoparticles reported thus far (mostly between 20-75% of ID). The urinary excretion and low RES accumulation of these nanoparticles in mice were indicated by in vivo CT imaging and biodistribution analysis. In summary, these ultrasmall Ag2S-NP can be effectively eliminated via urine and have high translational potential for various biomedical applications.
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影响因子：
11.4
作者：
Levard, Clement;Hotze, Ernest M.;Colman, Benjamin P.;Dale, Amy L.;Truong, Lisa;Yang, X. Y.;Bone, Audrey J.;Brown, Gordon E., Jr.;Tanguay, Robert L.;Di Giulio, Richard T.;Bernhardt, Emily S.;Meyer, Joel N.;Wiesner, Mark R.;Lowry, Gregory V.
通讯作者：
Lowry, Gregory V.
影响因子：
6.7
作者：
Hsu JC ;Naha PC ;Lau KC ;Chhour P ;Hastings R ;Moon BF ;Stein JM ;Witschey WRT ;McDonald ES ;Maidment ADA ;Cormode DP
通讯作者：
Cormode DP
二氧化硅封装的银纳米颗粒的开发是用于双能乳房X线摄影的对比剂。
影响因子：
5.9
作者：
Karunamuni R;Naha PC;Lau KC;Al-Zaki A;Popov AV;Delikatny EJ;Tsourkas A;Cormode DP;Maidment AD
通讯作者：
Maidment AD
影响因子：
10.8
作者：
Burns AA;Vider J;Ow H;Herz E;Penate-Medina O;Baumgart M;Larson SM;Wiesner U;Bradbury M
通讯作者：
Bradbury M
影响因子：
17.1
作者：
Cole, Lisa E.;Vargo-Gogola, Tracy;Roeder, Ryan K.
通讯作者：
Roeder, Ryan K.