Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.
Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.
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DOI：
10.3389/fncel.2021.770453
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发表时间：
2021
影响因子：
5.3
通讯作者：
Brumberg JC
中科院分区：
文献类型：
--
作者：
Chen CC;Brumberg JC
细胞结构为神经系统的功能提供了物理基础，它们的发育轨迹可能会受到生物体与之相互作用的外部环境特征的影响。历史和最近的工作已经确定，感觉经验，特别是在发育的关键时期，是至关重要的信息处理在大脑中，这反过来又深刻地影响神经元和非神经元皮质结构，随后影响动物的行为和认知输出。在这篇综述中，我们专注于如何改变感官体验影响正常/健康的中枢神经系统的发展，特别是专注于大脑皮层使用啮齿动物的胡须到桶系统作为一个说明性的模型。更好地理解结构可塑性，包括多个方面，如神经元，神经胶质和细胞外结构域，提供了一个更综合的观点，允许更深入地了解大脑的各个方面如何作为一个整体一起工作。
Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with. Historical and recent works have determined that sensory experiences, particularly during developmental critical periods, are crucial for information processing in the brain, which in turn profoundly influence neuronal and non-neuronal cortical structures that subsequently impact the animals’ behavioral and cognitive outputs. In this review, we focus on how altering sensory experience influences normal/healthy development of the central nervous system, particularly focusing on the cerebral cortex using the rodent whisker-to-barrel system as an illustrative model. A better understanding of structural plasticity, encompassing multiple aspects such as neuronal, glial, and extra-cellular domains, provides a more integrative view allowing for a deeper appreciation of how all aspects of the brain work together as a whole.
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影响因子：
7.1
作者：
Bachstetter AD;Van Eldik LJ;Schmitt FA;Neltner JH;Ighodaro ET;Webster SJ;Patel E;Abner EL;Kryscio RJ;Nelson PT
通讯作者：
Nelson PT
影响因子：
3.1
作者：
Chen, Chia-Chien;Tam, Danny;Brumberg, Joshua C.
通讯作者：
Brumberg, Joshua C.
树突状棘的超微结构：突触和脊柱形态之间的相关性。
影响因子：
4.3
作者：
Arellano JI;Benavides-Piccione R;Defelipe J;Yuste R
通讯作者：
Yuste R
影响因子：
3
作者：
Barrera, Kyrstle;Chu, Philip;Abramowitz, Jason;Steger, Robert;Ramos, Raddy L.;Brumberg, Joshua C.
通讯作者：
Brumberg, Joshua C.
影响因子：
3.3
作者：
Ballesteros-Yáñez, I;Benavides-Piccione, R;DeFelipe, J
通讯作者：
DeFelipe, J