Effects of psychotropic drugs on ocular parameters relevant to traffic safety: A systematic review.
Effects of psychotropic drugs on ocular parameters relevant to traffic safety: A systematic review.
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DOI：
10.1016/j.neubiorev.2022.104831
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发表时间：
2022-10
影响因子：
8.2
通讯作者：
Hayley, Amie C.
中科院分区：
文献类型：
--
作者：
Arkell, Thomas R.;Russell, Ashley Brooks;Downey, Luke A.;Shiferaw, Brook;Brown, Timothy;Sherrick, James;Hayley, Amie C.
驾驶是一项复杂的神经行为任务，需要快速选择、吸收和处理视觉信息。对于执行视觉引导行为（如驾驶）至关重要的眼球运动对精神药物的影响也很敏感。从2000年1月1日至2021年12月31日，对Embase（通过Ovid）、EBSCOHost、Psynet、Pubmed、Scopus和Web of Science数据库进行了检查。根据PRISMA指南进行研究选择、数据提取和Cochrane偏倚风险（RoB2）评估。该综述已前瞻性注册（CRD42021267554）。总共有36篇全文文章检查了六种主要精神药物类别对与驾驶相关的动眼肌参数测量的影响。中枢抑制物质以剂量依赖的方式影响动眼肌反应。精神兴奋剂提高视觉搜索行为的最大速度，但不是准确性。吸入Δ-9-tetrahydrocannabinol（四氢大麻酚）增加注意力不集中（眼跳不准确），但不一致地影响其他眼动参数。由于精神活性物质的使用，复合眼参数的改变可能会通过损害选择和处理动态视觉信息的能力而不同地损害驾驶过程中的性能精度。
Driving is a complex neurobehavioural task necessitating the rapid selection, uptake, and processing of visual information. Eye movements that are critical for the execution of visually guided behaviour such as driving are also sensitive to the effects of psychotropic substances. The Embase (via Ovid), EBSCOHost, Psynet, Pubmed, Scopus and Web of Science databases were examined from January 01st, 2000 to December 31st, 2021. Study selection, data extraction and Cochrane Risk of Bias (RoB2) assessments were conducted according to PRISMA guidelines. The review was prospectively registered (CRD42021267554). In total, 36 full-text articles examined the effects of six principal psychotropic drug classes on measures of oculomotor parameters relevant to driving. Centrally depressing substances affect oculomotor responses in a dose-dependent manner. Psychostimulants improve maximal speed, but not accuracy, of visual search behaviours. Inhaled Δ-9-tetrahydrocannabinol (THC) increases inattention (saccadic inaccuracy) but does not consistently affect other oculomotor parameters. Alterations to composite ocular parameters due to psychoactive substance usage likely differently compromises performance precision during driving through impaired ability to select and process dynamic visual information.
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影响因子：
6.8
作者：
Schmechtig A;Lees J;Perkins A;Altavilla A;Craig KJ;Dawson GR;William Deakin JF;Dourish CT;Evans LH;Koychev I;Weaver K;Smallman R;Walters J;Wilkinson LS;Morris R;Williams SC;Ettinger U
通讯作者：
Ettinger U
影响因子：
2.2
作者：
Davey, Jeremy D.;Armstrong, Kerry A.;Parkes, Alexander
通讯作者：
Parkes, Alexander
影响因子：
4.1
作者：
Bey, Katharina;Lippold, Julia, V;Ettinger, Ulrich
通讯作者：
Ettinger, Ulrich
影响因子：
4.1
作者：
Allman, Ava-Ann;Ettinger, Ulrich;O'Driscoll, Gillian A.
通讯作者：
O'Driscoll, Gillian A.
影响因子：
2.2
作者：
Cheng, Wing-Chi;Dao, Kwok-Leung
通讯作者：
Dao, Kwok-Leung