The Immunomodulatory Capacity of Induced Pluripotent Stem Cells in the Post-stroke Environment.
The Immunomodulatory Capacity of Induced Pluripotent Stem Cells in the Post-stroke Environment.
复制标题
诱导多能干细胞在中风后环境中的免疫调节能力。
DOI：
10.3389/fcell.2021.647415
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发表时间：
2021
影响因子：
5.5
通讯作者：
Hess DC
中科院分区：
文献类型：
--
作者：
Spellicy SE;Hess DC
炎症已被证明是缺血性和出血性中风发病机制的关键因素。这种连续和渐进的反应，以常驻免疫细胞的增殖和外周免疫群体的招募为标志，导致氧化应激增加和神经元细胞死亡。最近，旨在平息中风后炎症反应各个阶段的治疗方法已显示出希望，其中之一是分化诱导多能干细胞（iPSC）。虽然假设受损组织的直接再生和增强的神经发生包含 iPSC 的一些治疗潜力，但最近的证据表明对神经炎症具有显着的旁分泌作用。具体来说，对 iPSC、iPSC-神经祖细胞 (iPSC-NPC) 和 iPSC-神经上皮样干细胞 (iPSC-lt-NESC) 的研究表明，对促炎信号传导和内源性炎症细胞群（例如小胶质细胞）具有显着的免疫调节作用。本综述旨在研究 iPSC 在中风后环境中介导神经炎症的机制，并确定进一步研究的途径。
Inflammation has proven to be a key contributing factor to the pathogenesis of ischemic and hemorrhagic stroke. This sequential and progressive response, marked by proliferation of resident immune cells and recruitment of peripheral immune populations, results in increased oxidative stress, and neuronal cell death. Therapeutics aimed at quelling various stages of this post-stroke inflammatory response have shown promise recently, one of which being differentiated induced pluripotent stem cells (iPSCs). While direct repopulation of damaged tissues and enhanced neurogenesis are hypothesized to encompass some of the therapeutic potential of iPSCs, recent evidence has demonstrated a substantial paracrine effect on neuroinflammation. Specifically, investigation of iPSCs, iPSC-neural progenitor cells (iPSC-NPCs), and iPSC-neuroepithelial like stem cells (iPSC-lt-NESC) has demonstrated significant immunomodulation of proinflammatory signaling and endogenous inflammatory cell populations, such as microglia. This review aims to examine the mechanisms by which iPSCs mediate neuroinflammation in the post-stroke environment, as well as delineate avenues for further investigation.
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影响因子：
21.1
作者：
Zhang, Weiqi;Duan, Shunlei;Li, Ying;Xu, Xiuling;Qu, Jing;Zhang, Weizhou;Liu, Guang-Hui
通讯作者：
Liu, Guang-Hui
影响因子：
8.3
作者：
Boshuizen MCS;Steinberg GK
通讯作者：
Steinberg GK
影响因子：
4.3
作者：
Jiang, Mei;Lv, Lei;Dong, Qiang
通讯作者：
Dong, Qiang
影响因子：
1.2
作者：
Chiang, Terrance;Messing, Robert O.;Chou, Wen-Hai
通讯作者：
Chou, Wen-Hai
影响因子：
3.7
作者：
Eto S;Goto M;Soga M;Kaneko Y;Uehara Y;Mizuta H;Era T
通讯作者：
Era T