Physical activity over the life course and its association with cognitive performance and impairment in old age.
Physical activity over the life course and its association with cognitive performance and impairment in old age.
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DOI：
10.1111/j.1532-5415.2010.02903.x
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发表时间：
2010-07
影响因子：
6.3
通讯作者：
Yaffe K
中科院分区：
文献类型：
--
作者：
Middleton LE;Barnes DE;Lui LY;Yaffe K
确定生命过程中不同年龄阶段的身体活动与晚年认知障碍的关系。横断面研究美国四个地点。我们对9344名年龄≥65岁（平均71.6岁）、自我报告为青少年、30岁、50岁和晚年身体活动的女性进行了改良的迷你精神状态检查（mMMSE）。我们使用logistic回归来确定各年龄段身体活动状况与认知障碍可能性之间的关系（mMMSE评分>比平均值低1.5SD, mMMSE≤22）。模型根据年龄、教育程度、婚姻状况、糖尿病、高血压、抑郁症状、吸烟和体重指数进行了调整。与每次都不运动的女性相比，报告进行体育锻炼的女性晚年认知障碍患病率较低(青少年：8.5% vs. 16.7%；调整优势比（95%置信区间）：0.65 (0.53-0.80)；30岁：8.9% vs. 12.0%；0.80 (0.67 - -0.96);50岁：8.5% vs. 13.1%；0.71 (0.59 - -0.85);老年：8.2% vs. 15.9%；0.74(0.61 - -0.91))。当这四种情况一起分析时，青少年体育活动与晚年认知障碍的几率较低的关系最为密切（OR=0.73(0.58-0.92)）。然而，那些在青少年时期缺乏运动并在以后的生活中变得活跃的女性比那些保持不运动的女性患癌症的风险要低。在生命历程的任何阶段，特别是在青少年时期进行体育锻炼的女性，晚年出现认知障碍的可能性较低。干预措施应在生命早期和整个生命过程中促进身体活动。
To determine how physical activity at various ages over the life course is associated with cognitive impairment in late life. Cross-sectional study Four US sites. We administered a modified Mini-Mental State Examination (mMMSE) to 9344 women ≥65 years (mean 71.6 years) who self-reported teenage, age 30, age 50, and late life physical activity. We used logistic regressions to determine the association between physical activity status at each age and likelihood of cognitive impairment (mMMSE score >1.5SD below the mean, mMMSE≤22). Models were adjusted for age, education, marital status, diabetes, hypertension, depressive symptoms, smoking, and body mass index. Women who reported being physically active had lower prevalence of cognitive impairment in late life compared to women who were inactive at each time (teenage: 8.5% vs. 16.7%; adjusted Odds Ratio (95% Confidence Interval): 0.65 (0.53–0.80); age 30: 8.9% vs. 12.0%; 0.80 (0.67–0.96); age 50: 8.5% vs. 13.1%; 0.71 (0.59–0.85); old age: 8.2% vs. 15.9%; 0.74 (0.61–0.91)). When the four times were analyzed together, teenage physical activity was most strongly associated with lower odds of late-life cognitive impairment (OR=0.73 (0.58–0.92)). However, women who were physically inactive at teenage and became active in later life had lower risk than those who remained inactive. Women who reported being physically active at any point over the life course, and especially at teenage, have lower likelihood of cognitive impairment in late life. Interventions should promote physical activity early in life and throughout the life course.
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DOI：
10.1111/j.1460-9568.2008.06524.x
发表时间：
2008-12
期刊：
The European journal of neuroscience
影响因子：
--
作者：
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通讯作者：
Ying Z
DOI：
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