Particulate matter air pollution exposure, distance to road, and incident lung cancer in the nurses' health study cohort.
Particulate matter air pollution exposure, distance to road, and incident lung cancer in the nurses' health study cohort.
复制标题
DOI：
10.1289/ehp.1307490
复制
发表时间：
2014-09
影响因子：
10.4
通讯作者：
Laden F
中科院分区：
文献类型：
--
作者：
Puett RC;Hart JE;Yanosky JD;Spiegelman D;Wang M;Fisher JA;Hong B;Laden F
背景：大量文献表明，肺癌的风险与颗粒物和交通相关污染物有关。目标：我们研究了肺癌发病率与长期居住暴露于环境颗粒物和住宅距离道路，作为交通相关暴露的代理。研究方法：对于护士健康研究的参与者，我们估计了72个月的平均PM2.5，PM2.5-10和PM10暴露以及住宅到道路的距离。对1994年至2010年发生的肺癌病例进行了随访。调整考克斯比例风险模型的潜在混杂因素。检查了吸烟状态对效应的影响。结果：在1，510，027人年期间，在103，650名参与者中观察到2，155例肺癌事件。在完全校正的模型中，72个月平均PM10增加10 μg/m3 [风险比（HR）= 1.04; 95% CI：0.95，1.14]，PM2.5（HR = 1.06; 95%CI：0.91，1.25）或PM2.5-10（HR = 1.05; 95%CI：0.92，1.20）与肺癌呈正相关。当队列仅限于从不吸烟者和至少10年前戒烟的前吸烟者时，相关性似乎增加，其中PM2.5最强（PM10：HR = 1.15; 95% CI：1.00，1.32; PM2.5：HR = 1.37; 95% CI：1.06，1.77; PM2.5-10：HR = 1.11; 95% CI：0.90，1.37）。结果是最高的限制时，最流行的亚型，腺癌。与道路接近的风险不太一致。结论：我们的研究结果支持了其他研究的结果，这些研究表明与环境PM暴露相关的肺癌发病风险增加，特别是在从不吸烟和长期吸烟的人中。引文：Puett RC，哈特JE，Yanosky JD，Spiegelman D，Wang M，Fisher JA，Hong B，Laden F. 2014.护士健康研究队列中颗粒物空气污染暴露、道路距离和肺癌发病率环境健康展望122：926-932; http：dx.doi.org/10.1289/ehp.1307490
Background: A body of literature has suggested an elevated risk of lung cancer associated with particulate matter and traffic-related pollutants. Objective: We examined the relation of lung cancer incidence with long-term residential exposures to ambient particulate matter and residential distance to roadway, as a proxy for traffic-related exposures. Methods: For participants in the Nurses’ Health Study, a nationwide prospective cohort of women, we estimated 72-month average exposures to PM2.5, PM2.5–10, and PM10 and residential distance to road. Follow-up for incident cases of lung cancer occurred from 1994 through 2010. Cox proportional hazards models were adjusted for potential confounders. Effect modification by smoking status was examined. Results: During 1,510,027 person-years, 2,155 incident cases of lung cancer were observed among 103,650 participants. In fully adjusted models, a 10-μg/m3 increase in 72-month average PM10 [hazard ratio (HR) = 1.04; 95% CI: 0.95, 1.14], PM2.5 (HR = 1.06; 95% CI: 0.91, 1.25), or PM2.5–10 (HR = 1.05; 95% CI: 0.92, 1.20) was positively associated with lung cancer. When the cohort was restricted to never-smokers and to former smokers who had quit at least 10 years before, the associations appeared to increase and were strongest for PM2.5 (PM10: HR = 1.15; 95% CI: 1.00, 1.32; PM2.5: HR = 1.37; 95% CI: 1.06, 1.77; PM2.5–10: HR = 1.11; 95% CI: 0.90, 1.37). Results were most elevated when restricted to the most prevalent subtype, adenocarcinomas. Risks with roadway proximity were less consistent. Conclusions: Our findings support those from other studies indicating increased risk of incident lung cancer associated with ambient PM exposures, especially among never- and long-term former smokers. Citation: Puett RC, Hart JE, Yanosky JD, Spiegelman D, Wang M, Fisher JA, Hong B, Laden F. 2014. Particulate matter air pollution exposure, distance to road, and incident lung cancer in the Nurses’ Health Study Cohort. Environ Health Perspect 122:926–932; http://dx.doi.org/10.1289/ehp.1307490
登录
查看更多内容
影响因子：
4.9
作者：
Heinrich J;Thiering E;Rzehak P;Krämer U;Hochadel M;Rauchfuss KM;Gehring U;Wichmann HE
通讯作者：
Wichmann HE
影响因子：
4.9
作者：
López-Cima MF;García-Pérez J;Pérez-Gómez B;Aragonés N;López-Abente G;Tardón A;Pollán M
通讯作者：
Pollán M
DOI：
10.1164/rccm.201303-0609oc
发表时间：
2013-09-01
影响因子：
24.7
作者：
Jerrett, Michael;Burnett, Richard T.;Pope, C. Arden, III
通讯作者：
Pope, C. Arden, III
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
5.4
作者：
Hystad, Perry;Demers, Paul A.;Brauer, Michael
通讯作者：
Brauer, Michael