Zebrafish as a Vertebrate Model System to Evaluate Effects of Environmental Toxicants on Cardiac Development and Function.
Zebrafish as a Vertebrate Model System to Evaluate Effects of Environmental Toxicants on Cardiac Development and Function.
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DOI：
10.3390/ijms17122123
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发表时间：
2016-12-16
影响因子：
5.6
通讯作者：
Marrs JA
中科院分区：
文献类型：
--
作者：
Sarmah S;Marrs JA
环境污染是现代世界的一个严重问题，对公众健康构成重大威胁。在胚胎发育期间暴露于环境污染物尤其危险。虽然许多污染物已被证实为潜在的有毒物质，但环境中仍有新的化学品需要评估。心脏发育是一个极其敏感的过程，胚胎发育过程中暴露于环境有毒分子会影响心脏发育。先天性心脏缺陷是最常见的威胁生命的全球健康问题，病因大多未知。斑马鱼已成为研究物质毒性对脊椎动物发育，特别是心脏发育的宝贵模型。斑马鱼为毒理学研究提供了许多其他模型系统所没有的优势。许多实验室已经使用斑马鱼来研究环境中广泛存在的化学物质对心脏发育的影响，包括杀虫剂，纳米颗粒和各种有机污染物。在这里，我们回顾了斑马鱼在胚胎发育过程中暴露于外部分子导致心脏缺陷的影响，包括环境中普遍存在的化学物质和非法药物。已知或潜在的毒性机制，以及如何斑马鱼的研究可以用来提供心脏缺陷的机械理解进行了讨论。
Environmental pollution is a serious problem of the modern world that possesses a major threat to public health. Exposure to environmental pollutants during embryonic development is particularly risky. Although many pollutants have been verified as potential toxicants, there are new chemicals in the environment that need assessment. Heart development is an extremely sensitive process, which can be affected by environmentally toxic molecule exposure during embryonic development. Congenital heart defects are the most common life-threatening global health problems, and the etiology is mostly unknown. The zebrafish has emerged as an invaluable model to examine substance toxicity on vertebrate development, particularly on cardiac development. The zebrafish offers numerous advantages for toxicology research not found in other model systems. Many laboratories have used the zebrafish to study the effects of widespread chemicals in the environment on heart development, including pesticides, nanoparticles, and various organic pollutants. Here, we review the uses of the zebrafish in examining effects of exposure to external molecules during embryonic development in causing cardiac defects, including chemicals ubiquitous in the environment and illicit drugs. Known or potential mechanisms of toxicity and how zebrafish research can be used to provide mechanistic understanding of cardiac defects are discussed.
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影响因子：
2.7
作者：
Cavanaugh AM;Huang J;Chen JN
通讯作者：
Chen JN
影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
斑马鱼：一个灵活的平台，用于分析斑马鱼胚胎的心脏速率
影响因子：
4.6
作者：
De Luca E;Zaccaria GM;Hadhoud M;Rizzo G;Ponzini R;Morbiducci U;Santoro MM
通讯作者：
Santoro MM
影响因子：
5
作者：
Asharani, P. V.;Yi Lianwu;Valiyaveettil, Suresh
通讯作者：
Valiyaveettil, Suresh
影响因子：
4.5
作者：
Gerger, Courtney J.;Weber, Lynn P.
通讯作者：
Weber, Lynn P.