Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation.

Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation.
复制标题

DOI:
10.3389/fnins.2021.718465
复制
发表时间:
2021
影响因子:
4.3
通讯作者:
Fetz EE
Fetz EE
中科院分区:
医学2区
文献类型:
--
作者:
Shupe LE;Miles FP;Jones G;Yun R;Mishler J;Rembado I;Murphy RL;Perlmutter SI;Fetz EE

文献摘要

参考文献

被引文献

相似文献

为了解决许多神经假体应用,Neurochip 3(NC 3)是一种多通道双向脑机接口,可自主操作,并支持闭环活动依赖性刺激。它由四块电路板组成,其中填充了现成的组件,并且足够紧凑,可以携带在非人类灵长类动物(NHP)的头部。第三次国家信息通报有六个主要组成部分:(1)具有Intan生物物理信号放大器的模拟前端(16个差分或32个单端通道)和3轴加速度计,(2)由Cyclone V FPGA和Atmel SAM 4 MCU组成的数字控制系统,(3)存储容量为128 GB或更大的微型SD卡,(4)±60 V兼容的6通道差分刺激器,(5)支持长达24小时的自主操作的可充电电池组,以及(6)用于通信的红外收发器和串行端口。NC 3和早期版本已成功部署在许多闭环手术中,以诱导突触可塑性和桥接丢失的生物连接,以及提供活性依赖性颅内强化。这些加强或替换受损连接的范例在神经修复学和神经康复中有许多应用。
Toward addressing many neuroprosthetic applications, the Neurochip3 (NC3) is a multichannel bidirectional brain-computer interface that operates autonomously and can support closed-loop activity-dependent stimulation. It consists of four circuit boards populated with off-the-shelf components and is sufficiently compact to be carried on the head of a non-human primate (NHP). NC3 has six main components: (1) an analog front-end with an Intan biophysical signal amplifier (16 differential or 32 single-ended channels) and a 3-axis accelerometer, (2) a digital control system comprised of a Cyclone V FPGA and Atmel SAM4 MCU, (3) a micro SD Card for 128 GB or more storage, (4) a 6-channel differential stimulator with ±60 V compliance, (5) a rechargeable battery pack supporting autonomous operation for up to 24 h and, (6) infrared transceiver and serial ports for communication. The NC3 and earlier versions have been successfully deployed in many closed-loop operations to induce synaptic plasticity and bridge lost biological connections, as well as deliver activity-dependent intracranial reinforcement. These paradigms to strengthen or replace impaired connections have many applications in neuroprosthetics and neurorehabilitation.
DOI: 10.3389/fncir.2012.00098
发表时间: 2012
影响因子: 3.5
作者:
Newman JP;Zeller-Townson R;Fong MF;Arcot Desai S;Gross RE;Potter SM
通讯作者: Potter SM
DOI: 10.1038/nature07418
发表时间: 2008-12-04
期刊: NATURE
影响因子: 64.8
作者:
Moritz, Chet T.;Perlmutter, Steve I.;Fetz, Eberhard E.
通讯作者: Fetz, Eberhard E.
DOI: 10.1109/tnsre.2006.875547
发表时间: 2006-06-01
影响因子: 4.9
作者:
Jackson, Andrew;Moritz, Chet T.;Fetz, Eberhard E.
通讯作者: Fetz, Eberhard E.
DOI: 10.1073/pnas.1505383112
发表时间: 2015-09-29
影响因子: 11.1
作者:
McPherson, Jacob G.;Miller, Robert R.;Perlmutter, Steve I.
通讯作者: Perlmutter, Steve I.
DOI: 10.1109/tnsre.2009.2023293
发表时间: 2009-08-01
影响因子: 4.9
作者:
Chestek, Cynthia A.;Gilja, Vikash;Shenoy, Krishna V.
通讯作者: Shenoy, Krishna V.