Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
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跨膜蛋白 108 参与海马齿状回的成体神经发生
DOI：
10.1186/s13578-019-0272-4
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Shunqi Wang
中科院分区：
文献类型：
--
作者：
Zheng Yu;Dong Lin;Yanzi Zhong;Bin Luo;Shengsheng Liu;Erkang Fei;Xinsheng Lai;Suqi Zou;Shunqi Wang
研究背景跨膜蛋白108（transmembrane protein 108，Tmem 108）是精神分裂症、双相情感障碍和抑郁症等精神疾病的危险基因。然而，Tmem 108的病理生理机制在很大程度上是unknown.ResultsHere，我们调查了Tmem 108在海马齿状回的病理生理功能，通过usingTmem 108突变小鼠。Tmem 108在海马齿状回和CA 3区高表达。齿状回是成年神经发生的脑区，齿状回的异常成年神经发生与抑郁症有关。事实上，Tmem 108突变小鼠在悬尾试验和强迫游泳试验中的不动性低于野生型小鼠。BrdU和抗Ki 67抗体染色显示Tmem 108突变小鼠海马齿状回区的成年神经发生减少。qPCR结果显示，Tmem 108突变小鼠Wnt/β-Catenin信号通路中3个齿状回成体神经发生相关基因Axin 2、DISC 1和β-Catenin的表达降低。结论Tmem 108促进成人神经发生，在精神疾病中起着复杂的作用。
BackgroundTransmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.ResultsHere we investigated the pathophysiological function of Tmem108 in the hippocampal dentate gyrus by usingTmem108mutant mice. Tmem108 highly expressed in the dentate gyrus and CA3 of the hippocampus. Dentate gyrus is a brain region where adult neurogenesis occurs, and aberrant adult neurogenesis in dentate gyrus has been implicated in major depression disorder. Indeed,Tmem108mutant mice had lower immobility than wild type mice in tail suspension test and forced swimming test. BrdU and anti-Ki67 antibody staining indicated that adult neurogenesis of the hippocampal dentate gyrus region decreased in Tmem108 mutant mice. qPCR results showed that expression of Axin2, DISC1 and β-Catenin, three dentate gyrus adult neurogenesis related genes in Wnt/β-Catenin signaling pathway, decreased inTmem108mutant mice. Furthermore, Tmem108 enhanced free β-Catenin level in dual luciferase assay.ConclusionsThus, our data suggest that Tmem108 increases adult neurogenesis and plays a complexity role in psychiatric disorders.
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影响因子：
5.3
作者：
Varela-Nallar L;Inestrosa NC
通讯作者：
Inestrosa NC
DOI：
10.1016/j.jaac.2010.06.008
发表时间：
2010-09
影响因子：
13.3
作者：
Neale BM;Medland SE;Ripke S;Asherson P;Franke B;Lesch KP;Faraone SV;Nguyen TT;Schäfer H;Holmans P;Daly M;Steinhausen HC;Freitag C;Reif A;Renner TJ;Romanos M;Romanos J;Walitza S;Warnke A;Meyer J;Palmason H;Buitelaar J;Vasquez AA;Lambregts-Rommelse N;Gill M;Anney RJ;Langely K;O'Donovan M;Williams N;Owen M;Thapar A;Kent L;Sergeant J;Roeyers H;Mick E;Biederman J;Doyle A;Smalley S;Loo S;Hakonarson H;Elia J;Todorov A;Miranda A;Mulas F;Ebstein RP;Rothenberger A;Banaschewski T;Oades RD;Sonuga-Barke E;McGough J;Nisenbaum L;Middleton F;Hu X;Nelson S;Psychiatric GWAS Consortium: ADHD Subgroup
通讯作者：
Psychiatric GWAS Consortium: ADHD Subgroup
影响因子：
46.9
作者：
Tang, Tracy;Li, Li;de Sauvage, Frederic J.
通讯作者：
de Sauvage, Frederic J.
影响因子：
3.6
作者：
A. Tanti;C. Belzung
通讯作者：
A. Tanti;C. Belzung
成人神经发生和神经胶质发生：神经修养的可能机制。
影响因子：
2.4
作者：
Rusznák Z;Henskens W;Schofield E;Kim WS;Fu Y
通讯作者：
Fu Y