Procedures between training and reactivation influence the destabilization of instrumental sucrose memory.
Procedures between training and reactivation influence the destabilization of instrumental sucrose memory.
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DOI：
10.3389/fnbeh.2022.953629
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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记忆失稳和再巩固被认为是支持记忆更新的一个基本助记过程。工具性记忆最近被证明是不稳定的，在重新激活过程中涉及到工具性奖赏偶然性的变化。然而，工具性反应的获得和执行是在学习其他奖赏相关记忆的情况下发生的。这可能会影响给定的重新激活会话破坏先前学习的工具性记忆的能力。在这里，我们介绍了在雄性大鼠身上进行的一系列实验，这些实验涉及按FR1时间表训练超过10天的工具记忆，然后在强加了VR5强化时间表的会话中重新激活。当在VR5重新激活会话之前注射MK-801时，只有当重新激活会话发生在训练结束后48小时，而不是24小时时，它才可靠地损害随后的仪器性能。训练结束和上下文消退会话的重新激活会话、额外的VR5重新激活会话，或者甚至是与车辆一起操作和注射的简单经历，导致MK-801不再对测试性能产生遗忘效果。虽然我们还没有一个明确的过程和机制来支持这种明显的选择性的VR5过程的影响，以破坏工具记忆的影响，这进一步强调了需要更多地了解促进重新激活诱导的记忆不稳定的条件。
Memory destabilization and reconsolidation is hypothesized to be a fundamental mnemonic process that can underpin memory updating. Instrumental memories have been shown recently to be destabilized following a reactivation session that involves a change in instrumental reward contingency. However, the acquisition and performance of an instrumental response occurs in the presence of the learning of other reward-related memories. This may influence the ability of a given reactivation session to destabilize the previously learned instrumental memory. Here we present a series of experiments in male rats involving an instrumental memory trained on an FR1 schedule over 10 days, and then reactivated in a session that imposed a VR5 schedule of reinforcement. When MK-801 was injected prior to the VR5 reactivation session, it reliably impaired subsequent instrumental performance at test only when the reactivation session occurred 48 h, and not 24 h, after the end of training. The interposition between the end of training and the reactivation session of a context extinction session, an additional VR5 reactivation session, or indeed the simple experience of being handled and injected with vehicle, resulted in MK-801 no longer having an amnestic effect on test performance. While we do not have a clear account for the process and mechanism underpinning this apparent selectivity of the effect of the VR5 session to destabilize the instrumental memory, it does additionally highlight the need for greater understanding of the conditions that facilitate reactivation-induced memory destabilization.
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影响因子：
3.4
作者：
Exton-McGuinness MT;Lee JL
通讯作者：
Lee JL
DOI：
10.1101/lm.035543.114
发表时间：
2014-09
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Exton-McGuinness MT;Patton RC;Sacco LB;Lee JL
通讯作者：
Lee JL
影响因子：
56.9
作者：
Eisenberg, M;Kobilo, T;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
1.8
作者：
Bouton ME
通讯作者：
Bouton ME
影响因子：
16.2
作者：
Milekic, MH;Alberini, CM
通讯作者：
Alberini, CM