Ovariectomy changes the response to antidepressant drugs in tail suspension test in mice
Ovariectomy changes the response to antidepressant drugs in tail suspension test in mice
复制标题
卵巢切除术改变了小鼠尾部悬吊试验中抗抑郁药物的反应
DOI：
10.1080/09513590.2016.1197197
复制
发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Huang, S.
中科院分区：
文献类型：
--
作者：
Ye, Y.;Liu, X.;Liu, C.;Huang, S.
摘要抑郁症状在人的一生中是非常常见的，尤其是女性。更年期是一个更容易抑郁的时期。有数据表明，雌激素缺乏可能会增加抑郁症的易感性。我们通过悬尾试验（TST）研究了双侧卵巢切除（OVX）是否会改变小鼠的行为和抗抑郁药物的作用。我们评估了OVX后1周、2周和2个月的行为变化。在OVX后1周、2周和2个月评估多塞平、帕罗西汀和文拉法辛的行为反应。对照组、假手术组和去卵巢组在去卵巢后1周和2周的TST中不动持续时间无明显差异。但术后2个月时，OVX组大鼠不动时间明显长于对照组和假手术组。在OVX后1周和2周，仅观察到文拉法辛的抗抑郁反应，而帕罗西汀的反应在OVX后2个月增加。OVX小鼠对抗抑郁药物的反应强烈改变。目前的研究结果表明，并不是所有的抗抑郁药物都适用于雌激素缺乏的抑郁症。
Abstract Depressive symptoms are very frequent over a lifetime, especially for women. Menopause is a period of higher depressive vulnerability. There are suggestive data that estrogen deficiency may increase the susceptibility for depression. We studied whether a bilateral ovariectomy (OVX) modifies mice behaviors and antidepressant drug effects through tail suspension test (TST). We evaluated behavioral changes at 1 week, 2 weeks, and up to 2 months after OVX. The behavior responses to doxepin, paroxetine, and venlafaxine at 1 week, 2 weeks, and 2 months after OVX were evaluated. No obvious difference was detected on the duration of immobility among control group, sham group, and OVX group in the TST at 1 week and 2 weeks after OVX. But the duration of immobility of OVX group was distinctly longer than that of both control group and sham operation group at 2 months after OVX. At 1 and 2 weeks after OVX, only the antidepressant response to venlafaxine was observed, while response to paroxetine increased 2 months after OVX. Response to antidepressant drugs was strongly modified in OVX mice. The present results suggest that not all antidepressant drugs are appropriate for depression with estrogen deficiency.
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DOI：
10.1002/9781119870203.mpg003
发表时间：
2021-12
期刊：
The Maudsley Prescribing Guidelines in Psychiatry
影响因子：
--
作者：
O. Karamustafalıoğlu;H. Yumrukçal
通讯作者：
O. Karamustafalıoğlu;H. Yumrukçal
影响因子：
2
作者：
Nishizawa, Koji;Torii, Kosuke;Matsuoka, Masaaki
通讯作者：
Matsuoka, Masaaki
影响因子：
1.5
作者：
M. García-Portilla
通讯作者：
M. García-Portilla
影响因子：
3.4
作者：
STERU, L;CHERMAT, R;SIMON, P
通讯作者：
SIMON, P
影响因子：
4
作者：
K. Wilson;P. Mottram
通讯作者：
K. Wilson;P. Mottram