Understanding obesity and endometrial cancer risk: opportunities for prevention.

Understanding obesity and endometrial cancer risk: opportunities for prevention.
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DOI:
10.1016/j.ajog.2011.05.042
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发表时间:
2011-12
影响因子:
9.8
通讯作者:
Lu KH
Lu KH
中科院分区:
医学1区
文献类型:
--
作者:
Schmandt RE;Iglesias DA;Co NN;Lu KH

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在世界范围内,肥胖已成为一项重大的公共健康危机。超重和肥胖不仅会增加心血管疾病和2型糖尿病的风险,而且现在也是各种癌症类型的已知危险因素。在所有癌症中,体重指数的增加与子宫内膜癌的发病率和死亡率关系最为密切。脂肪组织和肥胖如何参与子宫内膜癌发病机制的分子机制正在得到更好的理解,并揭示了许多合理的策略,包括行为和药物,以预防原发和复发疾病。
Worldwide, obesity has become a major public health crisis. Overweight and obesity not only increase the risk of cardiovascular disease and type-2 diabetes, but also are now known risk factors for a variety of cancer types. Among all cancers, increasing body mass index is most strongly associated with endometrial cancer incidence and mortality. The molecular mechanisms underlying how adipose tissue and obesity contribute to the pathogenesis of endometrial cancer are becoming better understood and have revealed a number of rational strategies, both behavioral and pharmaceutical, for the prevention of both primary and recurrent disease.
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