Prenatal predictors of infant self-regulation: the contributions of placental DNA methylation of NR3C1 and neuroendocrine activity.
Prenatal predictors of infant self-regulation: the contributions of placental DNA methylation of NR3C1 and neuroendocrine activity.
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DOI：
10.3389/fnbeh.2015.00130
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发表时间：
2015
影响因子：
3
通讯作者：
Lester BM
中科院分区：
文献类型：
--
作者：
Conradt E;Fei M;LaGasse L;Tronick E;Guerin D;Gorman D;Marsit CJ;Lester BM
We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still-face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode was coded and pre-stress cortisol and cortisol reactivity was assessed in response to the still-face paradigm. A factor analysis of NR3C1 CpG sites revealed two factors: one for CpG sites 1–4 and the other for sites 5–13. DNA methylation of the factor comprising NR3C1 CpG sites 5–13 was related to greater cortisol reactivity and infant self-regulation, but cortisol reactivity was not associated with infant self-regulation. The results reveal that prenatal epigenetic processes may explain part of the development of infant self-regulation.
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影响因子：
4
作者：
Braungart-Rieker, J;Garwood, MM;Notaro, PC
通讯作者：
Notaro, PC
影响因子：
3.7
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通讯作者：
Lester BM
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Conradt, Elisabeth;Lester, Barry M.;Marsit, Carmen J.
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Marsit, Carmen J.