Behavioral and Cellular Tagging in Young and in Early Cognitive Aging.
Behavioral and Cellular Tagging in Young and in Early Cognitive Aging.
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DOI：
10.3389/fnagi.2022.809879
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发表时间：
2022
影响因子：
4.8
通讯作者：
Wang SH
中科院分区：
文献类型：
--
作者：
Gros A;Lim AWH;Hohendorf V;White N;Eckert M;McHugh TJ;Wang SH
日常维护相关信息的能力会受到老龄化的负面影响。然而，表现出幼龄动物记忆持久性和早期衰老记忆衰退的神经机制尚不完全清楚。当围绕日常记忆任务的编码引入新事件时，可以促进年轻时的记忆持久性，但不能促进早期衰老。在这里，我们通过将食欲延迟匹配任务中的行为训练与“通过荧光原位杂交对时间活动进行细胞区室分析”技术相结合，在雄性大鼠中研究了海马体的子区域如何参与行为标记中的记忆表征，以及早期衰老如何影响这种表征。我们发现，由记忆编码激活的神经元组件也被新奇事物部分激活，特别是在年轻雄性大鼠的远端 CA1 和近端 CA3 亚区。在衰老早期，编码和新奇触发的神经元数量均显着减少，对编码神经元的影响更为深远。因此，通过新颖性促进的记忆持久性将重叠的海马组件作为关键的细胞特征，而认知衰老与神经元激活的潜在减少有关。
The ability to maintain relevant information on a daily basis is negatively impacted by aging. However, the neuronal mechanism manifesting memory persistence in young animals and memory decline in early aging is not fully understood. A novel event, when introduced around encoding of an everyday memory task, can facilitate memory persistence in young age but not in early aging. Here, we investigated in male rats how sub-regions of the hippocampus are involved in memory representation in behavioral tagging and how early aging affects such representation by combining behavioral training in appetitive delayed-matching-to-place tasks with the “cellular compartment analysis of temporal activity by fluorescence in situ hybridization” technique. We show that neuronal assemblies activated by memory encoding were also partially activated by novelty, particularly in the distal CA1 and proximal CA3 subregions in young male rats. In early aging, both encoding- and novelty-triggered neuronal populations were significantly reduced with a more profound effect in encoding neurons. Thus, memory persistence through novelty facilitation engages overlapping hippocampal assemblies as a key cellular signature, and cognitive aging is associated with underlying reduction in neuronal activation.
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影响因子：
3.5
作者：
Burke, Sara N.;Maurer, Andrew P.;Barnes, Carol A.
通讯作者：
Barnes, Carol A.
影响因子：
7.7
作者：
Diamantaki, Maria;Frey, Markus;Burgalossi, Andrea
通讯作者：
Burgalossi, Andrea
影响因子：
2.5
作者：
Ihalainen, JA;Riekkinen, P;Feenstra, MGP
通讯作者：
Feenstra, MGP
影响因子：
15.9
作者：
Frey, U;Morris, RGM
通讯作者：
Morris, RGM
DOI：
10.1073/pnas.1114198109
发表时间：
2012-01-17
影响因子：
11.1
作者：
Almaguer-Melian, William;Bergado-Rosado, Jorge;Frey, Julietta U.
通讯作者：
Frey, Julietta U.