Accessory and main olfactory systems influences on predator odor-induced behavioral and endocrine stress responses in rats.
Accessory and main olfactory systems influences on predator odor-induced behavioral and endocrine stress responses in rats.
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DOI：
10.1016/j.bbr.2009.09.038
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发表时间：
2010-02-11
影响因子：
2.7
通讯作者：
Campeau, Serge
中科院分区：
文献类型：
--
作者：
Masini, Cher V.;Garcia, Robert J.;Sasse, Sarah K.;Nyhuis, Tara J.;Day, Heidi E. W.;Campeau, Serge
暴露于捕食者的气味是引起啮齿动物各种应激反应的非常有效的方法。我们之前发现雪貂的气味暴露会导致内分泌激素（皮质酮和促肾上腺皮质激素）和行为的变化。为了区分主要和辅助嗅觉系统在这些反应中的贡献，设计了研究来独立或同时干扰这两个系统。在实验 1 中，用 10% 硫酸锌 (ZnSO4) 处理雄性 Sprague-Dawley 大鼠，使啮齿类动物丧失嗅觉（无法嗅觉），同时保持副嗅觉区域完整；在实验 2 中，通过手术切除大鼠的犁鼻器官 (VNX)，以阻止副嗅觉处理，同时保持主嗅觉系统完整。在第三个实验中，通过在同一只老鼠身上结合这两个程序，主嗅觉区域和副嗅觉区域都被破坏。与草莓气味相比，单独使用 ZnSO4 处理或 VNX 都不能可靠地降低对雪貂气味增加的皮质酮反应，但组合使用时，可以做到这一点。这表明通过主嗅觉或辅助嗅觉系统的处理可以引发对雪貂气味的内分泌应激反应。单独使用 VNX 也不影响雪貂的行为反应。单独使用 ZnSO4 处理以及与 VNX 结合使用，都会导致雪貂和草莓气味的行为发生变化，从而使行为结果难以清晰解释。总的来说，这些研究表明主嗅觉系统和副嗅觉系统都介导对捕食者气味的神经内分泌反应。
Exposures to predator odors are very effective methods to evoke a variety of stress responses in rodents. We have previously found that ferret odor exposure leads to changes in endocrine hormones (corticosterone and ACTH) and behavior. To distinguish the contributions of the main and accessory olfactory systems in these responses, studies were designed to interfere with these two systems either independently, or simultaneously. Male Sprague-Dawley rats were treated with 10% zinc sulfate (ZnSO4), which renders rodents anosmic (unable to smell) while leaving the accessory olfactory areas intact, or saline, in experiment 1. In experiment 2, the vomeronasal organs of rats were surgically removed (VNX) to block accessory olfactory processing, while leaving the main olfactory system intact. And in the 3rd experiment both the main and accessory olfactory areas were disrupted by combining the two procedures in the same rats. Neither ZnSO4 treatment or VNX alone reliably reduced the increased corticosterone response to ferret odor compared to strawberry odor, but in combination, they did. This suggests that processing through the main or the accessory olfactory system can elicit the endocrine stress response to ferret odor. VNX alone also did not affect the behavioral responses to the ferret. ZnSO4 treatment, alone and in combination with VNX, led to changes in behavior in response to both ferret and strawberry odor, making the behavioral results less clearly interpretable. Overall these studies suggest that both the main and accessory olfactory systems mediate the neuroendocrine response to predator odor.
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影响因子：
2.9
作者：
FILE, SE;ZANGROSSI, H;MABBUTT, PS
通讯作者：
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影响因子：
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作者：
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