Structural and Functional Connectivity of Default Mode Network underlying the Cognitive Impairment in Late-onset Depression.
Structural and Functional Connectivity of Default Mode Network underlying the Cognitive Impairment in Late-onset Depression.
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迟发性抑郁症认知障碍背后的默认模式网络的结构和功能连接
DOI：
10.1038/srep37617
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发表时间：
2016-11-25
影响因子：
4.6
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Yin Y;He X;Xu M;Hou Z;Song X;Sui Y;Liu Z;Jiang W;Yue Y;Zhang Y;Liu Y;Yuan Y
为探讨晚发性抑郁症（LOD）患者认知功能损害与默认模式网络（DMN）结构和功能改变的关系，对32例LOD患者和39例正常对照者进行静息态fMRI、DTI扫描和认知功能评估。基于种子的相关性分析进行探索的功能连接（FC）的DMN。FC受损区域之间的确定性纤维束成像进行检查的结构连接（SC）。偏相关分析，以评估这些改变FC和SC的认知协会。与对照组相比，LOD患者表现出减少DMN和扣带-鳃盖网络（CON）之间的FC，以及丘脑。LOD患者DMN与CON之间的连接纤维束FA减少，RD增加。DMN-CON FC和纤维束FA、RD均与认知成绩显著相关。因此，LOD的认知功能障碍可能与DMN和CON之间的FC降低有关，这可能是白色物质脱髓鞘的结果。
To identify the association between the functional and structural changes of default mode network (DMN) underlying the cognitive impairment in Late-onset depression (LOD), 32 LOD patients and 39 normal controls were recruited and underwent resting-state fMRI, DTI scans, and cognitive assessments. Seed-based correlation analysis was conducted to explore the functional connectivity (FC) of the DMN. Deterministic tractography between FC-impaired regions was performed to examine the structural connectivity (SC). Partial correlation analyses were employed to evaluate the cognitive association of those altered FC and SC. Compared with controls, LOD patients showed decreased FC between DMN and the cingulo-opercular network (CON), as well as the thalamus. Decreased FA and increased RD of these fiber tracts connecting DMN with CON were found in LOD patient. The DMN-CON FC and the FA, RD of the fiber tracts were both significantly correlated with the cognitive performance. Therefore, the cognitive impairment in LOD might be associated with the decreased FC between the DMN and the CON, which probably resulted from the demyelination of the white matter.
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老年抑郁症缓解后后扣带皮层全脑功能连接网络的异常改变模式：一项纵向研究
影响因子：
5.5
作者：
Jiang, Wen-Hao;Yuan, Yong-Gui;Zhang, Zhi-Jun
通讯作者：
Zhang, Zhi-Jun
影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
2.5
作者：
He X;Liu W;Li X;Li Q;Liu F;Rauh VA;Yin D;Bansal R;Duan Y;Kangarlu A;Peterson BS;Xu D
通讯作者：
Xu D
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
6.6
作者：
Colloby, Sean J.;Firbank, Michael J.;O'Brien, John T.
通讯作者：
O'Brien, John T.