Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis.
Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis.
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DOI：
10.1186/1546-0096-10-29
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发表时间：
2012-08-29
期刊：
影响因子：
--
通讯作者：
Prahalad S
中科院分区：
文献类型：
--
作者：
Tebo AE;Jaskowski T;Davis KW;Whiting A;Clifford B;Zeft A;McNally B;Hill HR;Bohnsack J;Prahalad S
抗瓜氨酸化蛋白/肽抗体（ACPA）对类风湿关节炎（RA）具有高特异性。一些患有幼年特发性关节炎（JIA）的儿童，在表型上与RA相似，类风湿因子（RF）检测呈阳性，类风湿因子是RA的特征生物标志物。我们在一个特征明确的JIA队列中调查了ACPA的患病率及其与RA相关的其他血清学标志物的关系。JIA患儿334例，其中RF +多关节JIA 30例。采用ELISA法检测所有病例和50例健康儿童对照血清中抗环瓜氨酸肽（anti-CCP） IgG、RF IgM、IgA和IgG、抗ra33 IgG和抗核抗体（ANA）。病例和对照组之间的比较使用卡方检验或Fisher精确检验和t检验。对照组中RF患病率为8%，病例中患病率为12% （ns）。对照组ACPA患病率为2%，病例患病率为14.3% （OR 8.2, p <0.01）。ACPA阳性和RF阴性的儿童（n = 23）的发病年龄明显更早（4.6岁对12.1岁，p <0.00001）， HLA-DRB1共享表位等位基因少于RF和ACPA阳性的儿童（n = 25）。抗ra33的患病率在病例和对照组之间没有差异。在14%的JIA患儿中可检出acpa。ACPA阳性但RF阴性的儿童很常见，这可能是JIA儿童的一个独特亚群。ACPA检测应纳入JIA分类。
Anti-citrullinated protein/peptide antibodies (ACPA), have high specificity for rheumatoid arthritis (RA). Some children with juvenile idiopathic arthritis (JIA), phenotypically resemble RA and test positive for rheumatoid factor (RF) a characteristic biomarker of RA. We investigated the prevalence of ACPA and its relationship to other serologic markers associated with RA in a well-characterized JIA cohort. Cases were 334 children with JIA, 30 of whom had RF + polyarticular JIA. Sera from all cases and 50 healthy pediatric controls were investigated by ELISA at a single time point for anti-cyclic citrullinated peptide (anti-CCP) IgG, RF IgM, IgA and IgG, anti-RA33 IgG, and antinuclear antibodies (ANA). Comparisons between cases and controls were made using Chi-square or Fisher exact tests and T-tests. The prevalence of RF was 8% among controls, and 12% among cases (ns). The prevalence of ACPA was 2% in controls and 14.3% in cases (OR 8.2, p <0.01). Children who were ACPA-positive and RF-negative (n = 23) had a significantly earlier onset-age (4.6 years vs. 12.1 years, p <0.00001) and had fewer HLA-DRB1 shared epitope alleles than those positive for both RF and ACPA (n = 25). Prevalence of anti-RA33 was not different between cases and controls. ACPAs are detectable in 14% of children with JIA. Children with positive ACPA but negative RF are frequent, and may define a distinct subset of children with JIA. ACPA testing should be included in the classification of JIA.
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影响因子：
27.4
作者：
NESHER, G;MOORE, TL;OSBORN, TG
通讯作者：
OSBORN, TG
影响因子：
27.4
作者：
GABAY, C;PRIEUR, AM;MEYER, O
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MEYER, O
影响因子：
3.5
作者：
Hromadnikova, I;Stechova, K;Vavrinec, J
通讯作者：
Vavrinec, J
影响因子：
2.2
作者：
Ozawa, Remi;Inaba, Yutaka;Yokota, Shumpei
通讯作者：
Yokota, Shumpei
影响因子：
2.5
作者：
Gilliam, Brooke E.;Reed, Melinda R.;Moore, Terry L.
通讯作者：
Moore, Terry L.