The role of dietary fat throughout the prostate cancer trajectory.
The role of dietary fat throughout the prostate cancer trajectory.
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DOI：
10.3390/nu6126095
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发表时间：
2014-12-22
期刊：
影响因子：
5.9
通讯作者：
Mourtzakis M
中科院分区：
文献类型：
--
作者：
Di Sebastiano KM;Mourtzakis M
前列腺癌是世界范围内诊断的第二大常见癌症;然而，患者表现出极高的存活率。许多生活方式因素，包括肥胖和饮食，被认为是晚期前列腺癌的危险因素。膳食脂肪是肥胖的根本原因，对前列腺癌患者可能特别重要。前列腺癌治疗可能导致身体成分的变化，通过增加合并症（如心血管疾病和糖尿病）的风险来影响幸存者的生活质量。我们的目标是检查整个前列腺癌治疗轨迹中的膳食脂肪，包括风险，癌症发展和生存率。在整个前列腺癌发展轨迹中关注一种特定的营养素，为前列腺癌中的膳食脂肪以及可能加剧前列腺癌风险、进展和复发的机制提供了独特的视角。通过这种方法，我们注意到膳食脂肪的高摄入，特别是动物脂肪和饱和脂肪的高摄入，可能与前列腺癌风险增加有关。相比之下，低脂饮食，特别是低饱和脂肪，可能通过减少肿瘤血管生成和癌症复发对前列腺癌幸存者有益。胰岛素样生长因子（IGF）/Akt信号通路似乎是调节膳食脂肪摄入和前列腺癌发生和进展的关键通路。
Prostate cancer is the second most common cancer diagnosed world-wide; however, patients demonstrate exceptionally high survival rates. Many lifestyle factors, including obesity and diet, are considered risk factors for advanced prostate cancer. Dietary fat is a fundamental contributor to obesity and may be specifically important for prostate cancer patients. Prostate cancer treatment can result in changes in body composition, affecting quality of life for survivors by increasing the risk of co-morbidities, like cardiovascular disease and diabetes. We aim to examine dietary fat throughout the prostate cancer treatment trajectory, including risk, cancer development and survivorship. Focusing on one specific nutrient throughout the prostate cancer trajectory provides a unique perspective of dietary fat in prostate cancer and the mechanisms that may exacerbate prostate cancer risk, progression and recurrence. Through this approach, we noted that high intake of dietary fat, especially, high intake of animal and saturated fats, may be associated with increased prostate cancer risk. In contrast, a low-fat diet, specifically low in saturated fat, may be beneficial for prostate cancer survivors by reducing tumor angiogenesis and cancer recurrence. The insulin-like growth factor (IGF)/Akt signaling pathway appears to be the key pathway moderating dietary fat intake and prostate cancer development and progression.
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影响因子：
4.7
作者：
Akinsete JA;Ion G;Witte TR;Hardman WE
通讯作者：
Hardman WE
DOI：
10.1158/1055-9965.epi-08-0008
发表时间：
2008-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Demark-Wahnefried W;Polascik TJ;George SL;Switzer BR;Madden JF;Ruffin MT 4th;Snyder DC;Owzar K;Hars V;Albala DM;Walther PJ;Robertson CN;Moul JW;Dunn BK;Brenner D;Minasian L;Stella P;Vollmer RT
通讯作者：
Vollmer RT
影响因子：
3.8
作者：
Chavarro, Jorge E.;Stampfer, Meir J.;Ma, Jing
通讯作者：
Ma, Jing
影响因子：
4.3
作者：
Chatterjee, B
通讯作者：
Chatterjee, B
DOI：
10.1016/j.juro.2009.08.104
发表时间：
2010-01
期刊：
The Journal of urology
影响因子：
--
作者：
Aronson WJ;Barnard RJ;Freedland SJ;Henning S;Elashoff D;Jardack PM;Cohen P;Heber D;Kobayashi N
通讯作者：
Kobayashi N