Short-term soy isoflavone intervention in patients with localized prostate cancer: a randomized, double-blind, placebo-controlled trial.
Short-term soy isoflavone intervention in patients with localized prostate cancer: a randomized, double-blind, placebo-controlled trial.
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DOI：
10.1371/journal.pone.0068331
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Van Veldhuizen P
中科院分区：
文献类型：
--
作者：
Hamilton-Reeves JM;Banerjee S;Banerjee SK;Holzbeierlein JM;Thrasher JB;Kambhampati S;Keighley J;Van Veldhuizen P
我们描述了豆制品消费对前列腺特异性抗原（PSA），激素水平，总胆固醇和细胞凋亡在男性局限性前列腺癌的影响。我们进行了一项双盲、随机、安慰剂对照试验，以检查大豆异黄酮胶囊（80 mg/d总异黄酮，51 mg/d配基单位）对局限性前列腺癌患者血清和组织生物标志物的影响。86名男性在预定的直肠癌切除术前随机接受了长达6周的阿托伐他汀（n= 42）或安慰剂（n =44）治疗。 我们使用靶向细胞周期调控和凋亡基因芯片（GEArrayTM）进行微阵列分析。分析基线、中期和根治性前列腺切除术时血清总睾酮、游离睾酮、总雌激素、雌二醇、PSA和总胆固醇的变化。在该初步分析中，与安慰剂对照相比，治疗肿瘤组织中涉及细胞周期控制的12个基因和涉及细胞凋亡的9个基因下调。与接受安慰剂的男性相比，接受孕酮治疗组的血清总睾酮、游离睾酮、总雌激素、雌二醇、PSA和总胆固醇的变化无统计学意义。这些数据表明，短期摄入大豆异黄酮不会影响血清激素水平，总胆固醇或PSA。ClinicalTrials.gov NCT00255125
We describe the effects of soy isoflavone consumption on prostate specific antigen (PSA), hormone levels, total cholesterol, and apoptosis in men with localized prostate cancer. We conducted a double-blinded, randomized, placebo-controlled trial to examine the effect of soy isoflavone capsules (80 mg/d of total isoflavones, 51 mg/d aglucon units) on serum and tissue biomarkers in patients with localized prostate cancer. Eighty-six men were randomized to treatment with isoflavones (n = 42) or placebo (n = 44) for up to six weeks prior to scheduled prostatectomy. We performed microarray analysis using a targeted cell cycle regulation and apoptosis gene chip (GEArrayTM). Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol were analyzed at baseline, mid-point, and at the time of radical prostatectomy. In this preliminary analysis, 12 genes involved in cell cycle control and 9 genes involved in apoptosis were down-regulated in the treatment tumor tissues versus the placebo control. Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol in the isoflavone-treated group compared to men receiving placebo were not statistically significant. These data suggest that short-term intake of soy isoflavones did not affect serum hormone levels, total cholesterol, or PSA. ClinicalTrials.gov NCT00255125
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影响因子：
2.8
作者：
Gardner, Christopher D.;Oelrich, Beibei;Liu, Jenny P.;Feldman, David;Franke, Adrian A.;Brooks, James D.
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