Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
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DOI：
10.1126/science.abk2432
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发表时间：
2022-03-04
期刊：
影响因子：
--
通讯作者：
Zinzen RP
中科院分区：
文献类型：
--
作者：
Li H;Janssens J;De Waegeneer M;Kolluru SS;Davie K;Gardeux V;Saelens W;David FPA;Brbić M;Spanier K;Leskovec J;McLaughlin CN;Xie Q;Jones RC;Brueckner K;Shim J;Tattikota SG;Schnorrer F;Rust K;Nystul TG;Carvalho-Santos Z;Ribeiro C;Pal S;Mahadevaraju S;Przytycka TM;Allen AM;Goodwin SF;Berry CW;Fuller MT;White-Cooper H;Matunis EL;DiNardo S;Galenza A;O'Brien LE;Dow JAT;FCA Consortium§;Jasper H;Oliver B;Perrimon N;Deplancke B;Quake SR;Luo L;Aerts S;Agarwal D;Ahmed-Braimah Y;Arbeitman M;Ariss MM;Augsburger J;Ayush K;Baker CC;Banisch T;Birker K;Bodmer R;Bolival B;Brantley SE;Brill JA;Brown NC;Buehner NA;Cai XT;Cardoso-Figueiredo R;Casares F;Chang A;Clandinin TR;Crasta S;Desplan C;Detweiler AM;Dhakan DB;Donà E;Engert S;Floc'hlay S;George N;González-Segarra AJ;Groves AK;Gumbin S;Guo Y;Harris DE;Heifetz Y;Holtz SL;Horns F;Hudry B;Hung RJ;Jan YN;Jaszczak JS;Jefferis GSXE;Karkanias J;Karr TL;Katheder NS;Kezos J;Kim AA;Kim SK;Kockel L;Konstantinides N;Kornberg TB;Krause HM;Labott AT;Laturney M;Lehmann R;Leinwand S;Li J;Li JSS;Li K;Li K;Li L;Li T;Litovchenko M;Liu HH;Liu Y;Lu TC;Manning J;Mase A;Matera-Vatnick M;Matias NR;McDonough-Goldstein CE;McGeever A;McLachlan AD;Moreno-Roman P;Neff N;Neville M;Ngo S;Nielsen T;O'Brien CE;Osumi-Sutherland D;Özel MN;Papatheodorou I;Petkovic M;Pilgrim C;Pisco AO;Reisenman C;Sanders EN;Dos Santos G;Scott K;Sherlekar A;Shiu P;Sims D;Sit RV;Slaidina M;Smith HE;Sterne G;Su YH;Sutton D;Tamayo M;Tan M;Tastekin I;Treiber C;Vacek D;Vogler G;Waddell S;Wang W;Wilson RI;Wolfner MF;Wong YE;Xie A;Xu J;Yamamoto S;Yan J;Yao Z;Yoda K;Zhu R;Zinzen RP
100多年来，果蝇一直是研究最多的模式生物之一。在这里，我们提供了一个成虫果蝇的单细胞图谱，它包括来自15个单独解剖的性组织以及整个头部和身体的58万个细胞核，注释为>；250不同的细胞类型。我们提供了对整个动物与细胞类型相关的基因签名和转录因子标记，以及性别二型性的深入分析。对组织之间常见的细胞类型的分析，如血液和肌肉细胞，揭示了罕见的细胞类型和组织特有的亚型。这份图谱为整个果蝇群落提供了宝贵的资源，并为在单细胞分辨率下研究遗传扰动和疾病模型提供了参考。整个成年果蝇的单核转录图谱
For over 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here we present a single cell atlas of the adult fly, Tabula Drosophilae, that includes 580k nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the entire Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution. A single-nucleus transcriptomic map of the entire adult Drosophila melanogaster
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影响因子：
64.5
作者：
Davie K;Janssens J;Koldere D;De Waegeneer M;Pech U;Kreft Ł;Aibar S;Makhzami S;Christiaens V;Bravo González-Blas C;Poovathingal S;Hulselmans G;Spanier KI;Moerman T;Vanspauwen B;Geurs S;Voet T;Lammertyn J;Thienpont B;Liu S;Konstantinides N;Fiers M;Verstreken P;Aerts S
通讯作者：
Aerts S
影响因子：
8.8
作者：
Jenett, Arnim;Rubin, Gerald M.;Zugates, Christopher T.
通讯作者：
Zugates, Christopher T.
影响因子：
64.8
作者：
Graveley BR;Brooks AN;Carlson JW;Duff MO;Landolin JM;Yang L;Artieri CG;van Baren MJ;Boley N;Booth BW;Brown JB;Cherbas L;Davis CA;Dobin A;Li R;Lin W;Malone JH;Mattiuzzo NR;Miller D;Sturgill D;Tuch BB;Zaleski C;Zhang D;Blanchette M;Dudoit S;Eads B;Green RE;Hammonds A;Jiang L;Kapranov P;Langton L;Perrimon N;Sandler JE;Wan KH;Willingham A;Zhang Y;Zou Y;Andrews J;Bickel PJ;Brenner SE;Brent MR;Cherbas P;Gingeras TR;Hoskins RA;Kaufman TC;Oliver B;Celniker SE
通讯作者：
Celniker SE
影响因子：
1.9
作者：
Costa M;Reeve S;Grumbling G;Osumi-Sutherland D
通讯作者：
Osumi-Sutherland D
影响因子：
14.9
作者：
Henry GL;Davis FP;Picard S;Eddy SR
通讯作者：
Eddy SR