The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.
The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.
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DOI：
10.1111/ejn.14907
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发表时间：
2021-10
影响因子：
3.4
通讯作者：
Maffei, Arianna
中科院分区：
文献类型：
--
作者：
Capogna, Marco;Castillo, Pablo E.;Maffei, Arianna
GABA能中间神经元具有高度的多样性，它们的突触输出表现出各种形式的可塑性。令人信服的证据表明，抑制性突触传递的活动依赖性变化在调节与学习和记忆密切相关的神经回路以及回路精化方面发挥着重要作用。在这里，我们提供了抑制性突触可塑性的最新概述，重点放在海马体和新皮质。为了说明抑制性中间神经元的多样性，我们讨论了两种高度分化的中间神经元类型，即表达小白蛋白的篮状细胞和神经胶质样细胞，它们在电路动力学中具有独特的作用。我们还介绍了最新的分子机制的基础上，长期的，活动依赖的可塑性的快速抑制传递。最后，我们讨论了抑制性突触可塑性在神经元回路功能中的作用。目前的情况是，中枢神经系统中的抑制性突触传递极其多样化，经历了各种机械上不同形式的可塑性，并有助于发挥比最初认为的更精细的计算作用。抑制性中间神经元的显著多样性和GABA能突触表达的各种形式的可塑性都提供了令人惊讶的丰富的抑制谱系，这是包括记忆在内的各种复杂神经回路功能的核心。
GABAergic interneurons are highly diverse and their synaptic outputs express various forms of plasticity. Compelling evidence indicates that activity-dependent changes of inhibitory synaptic transmission play a significant role in regulating neural circuits critically involved in learning and memory and circuit refinement. Here, we provide an updated overview of inhibitory synaptic plasticity with a focus on the hippocampus and neocortex. To illustrate the diversity of inhibitory interneurons, we discuss the case of two highly divergent interneuron types, parvalbumin-expressing basket cells and neurogliaform cells, which support unique roles on circuit dynamics. We also present recent progress on the molecular mechanisms underlying long-term, activity-dependent plasticity of fast inhibitory transmission. Lastly, we discuss the role of inhibitory synaptic plasticity in neuronal circuits’ function. The emerging picture is that inhibitory synaptic transmission in the CNS is extremely diverse, undergoes various mechanistically distinct forms of plasticity, and contributes to a much more refined computational role than initially thought. Both the remarkable diversity of inhibitory interneurons and the various forms of plasticity expressed by GABAergic synapses provide an amazingly rich inhibitory repertoire that is central to a variety of complex neural circuit functions, including memory.
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影响因子：
16.2
作者：
Atallah BV;Bruns W;Carandini M;Scanziani M
通讯作者：
Scanziani M
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影响因子：
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作者：
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de Arcangelis, L.
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16.2
作者：
Aizenman, CD;Manis, PB;Linden, DJ
通讯作者：
Linden, DJ
影响因子：
34.7
作者：
Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael