Large-scale brain networks underlying language acquisition in early infancy.
Large-scale brain networks underlying language acquisition in early infancy.
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DOI：
10.3389/fpsyg.2011.00093
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发表时间：
2011
影响因子：
3.8
通讯作者：
Taga G
中科院分区：
文献类型：
--
作者：
Homae F;Watanabe H;Nakano T;Taga G
人类发展中的一个关键问题是，左侧额叶和颞区的语言相关区域是否在言语前婴儿中起到了功能网络的作用。在这里，我们使用94个通道的近红外光谱来揭示睡眠中的3个月大婴儿大脑中的功能网络，这些婴儿有声音和没有声音。在前3 分钟内，我们测量了自发脑活动(周期1)。在时段1之后，我们通过播放3 分钟的日语句子来提供刺激(时段2)。最后，我们在没有提供刺激的情况下(时段3)测量了3 分钟的脑激活，就像在时段1中一样。我们发现，当婴儿听到语音时，不仅两侧的颞区和顶区，而且前额区和枕区的氧合血红蛋白信号增加，去氧合血红蛋白信号减少。通过计算通道间OXY-HB信号的时滞互相关和相干性，我们测试了三个周期的功能连通性。在周期1中，相邻通道和对侧大脑半球对应通道的OXY-Hb信号显示出较高的相关系数，在周期2中也观察到类似的相关性，但同侧大脑半球中显示高相关性的通道数目较多，尤其是在前后方向。在周期3中，额区和颞区之间的功能连接关系密切，而在周期1中，这种关系不那么显著，这表明这些区域形成了功能网络，并作为一个具有先前输入记忆的滞后系统发挥作用。我们提出了一个假设，即包括额叶和颞区在内的时空大规模脑网络是婴儿语言处理的基础，它们可能在婴儿时期的语言习得中发挥重要作用。
A critical issue in human development is that of whether the language-related areas in the left frontal and temporal regions work as a functional network in preverbal infants. Here, we used 94-channel near-infrared spectroscopy to reveal the functional networks in the brains of sleeping 3-month-old infants with and without presenting speech sounds. During the first 3 min, we measured spontaneous brain activation (period 1). After period 1, we provided stimuli by playing Japanese sentences for 3 min (period 2). Finally, we measured brain activation for 3 min without providing the stimulus (period 3), as in period 1. We found that not only the bilateral temporal and temporoparietal regions but also the prefrontal and occipital regions showed oxygenated hemoglobin signal increases and deoxygenated hemoglobin signal decreases when speech sounds were presented to infants. By calculating time-lagged cross-correlations and coherences of oxy-Hb signals between channels, we tested the functional connectivity for the three periods. The oxy-Hb signals in neighboring channels, as well as their homologous channels in the contralateral hemisphere, showed high correlation coefficients in period 1. Similar correlations were observed in period 2; however, the number of channels showing high correlations was higher in the ipsilateral hemisphere, especially in the anterior–posterior direction. The functional connectivity in period 3 showed a close relationship between the frontal and temporal regions, which was less prominent in period 1, indicating that these regions form the functional networks and work as a hysteresis system that has memory of the previous inputs. We propose a hypothesis that the spatiotemporally large-scale brain networks, including the frontal and temporal regions, underlie speech processing in infants and they might play important roles in language acquisition during infancy.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
5.3
作者：
Baier, Bernhard;Kleinschmidt, Andreas;Mueller, Notger G.
通讯作者：
Mueller, Notger G.
DOI：
10.1073/pnas.0606302103
发表时间：
2006-09-19
影响因子：
11.1
作者：
Dehaene-Lambertz, Ghislaine;Hertz-Pannier, Lucie;Dehaene, Stanislas
通讯作者：
Dehaene, Stanislas
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo