Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
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DOI：
10.1002/hbm.22360
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发表时间：
2014-06
影响因子：
4.8
通讯作者：
Liu, Chunlei
中科院分区：
文献类型：
--
作者：
Li, Wei;Wu, Bing;Batrachenko, Anastasia;Bancroft-Wu, Vivian;Morey, Rajendra A.;Shashi, Vandana;Langkammer, Christian;De Bellis, Michael D.;Ropele, Stefan;Song, Allen W.;Liu, Chunlei
最近的几项研究表明，大脑的磁化率主要受白色物质中的髓鞘和深核中的铁沉积的影响。脑中的髓鞘形成和铁沉积在空间上和时间上都发生演变。这种演变反映了正常大脑发育和衰老的一个重要特征。在这项研究中，我们通过检查从1岁到83岁的发育和衰老过程，评估了人体大脑中区域易感性的变化。磁化率在这一寿命的演变被发现显示灰色和白色物质之间的差异轨迹。在皮质和皮质下的白色物质中，观察到磁化率的初始降低，随后增加，这可以通过泊松曲线拟合。在灰质中，包括皮质灰质和富铁的深核，磁化率表现出单调增加，可以用指数增长来描述。变化率根据大脑的功能和解剖区域而变化。在脑核团中，敏感性随年龄的变化与R2* 测量的结果一致。我们的研究结果表明，磁化率可能提供有价值的信息，在大脑成熟和衰老过程中的脑髓鞘和铁沉积的空间和时间模式。
As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and iron deposition in the brain evolve both spatially and temporally. This evolution reflects an important characteristic of normal brain development and ageing. In this study, we assessed the changes of regional susceptibility in the human brain in vivo by examining the developmental and ageing process from 1 to 83 years of age. The evolution of magnetic susceptibility over this lifespan was found to display differential trajectories between the gray and the white matter. In both cortical and subcortical white matter, an initial decrease followed by a subsequent increase in magnetic susceptibility was observed, which could be fitted by a Poisson curve. In the gray matter, including the cortical gray matter and the iron-rich deep nuclei, magnetic susceptibility displayed a monotonic increase that can be described by an exponential growth. The rate of change varied according to functional and anatomical regions of the brain. For the brain nuclei, the age-related changes of susceptibility were in good agreement with the findings from R2* measurement. Our results suggest that magnetic susceptibility may provide valuable information regarding the spatial and temporal patterns of brain myelination and iron deposition during brain maturation and ageing.
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DOI：
10.1073/pnas.0910222107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Lee, Jongho;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
DOI：
10.1016/0165-3806(92)90079-c
发表时间：
1992-04-24
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
COWELL, PE;ALLEN, LS;DENENBERG, VH
通讯作者：
DENENBERG, VH
影响因子：
19.7
作者：
Aquino, Domenico;Bizzi, Alberto;Chiapparini, Luisa
通讯作者：
Chiapparini, Luisa
影响因子：
4.4
作者：
Haacke, E. Mark;Miao, Yanwei;Liu, Manju;Habib, Charbel A.;Katkuri, Yashwanth;Liu, Ting;Yang, Zhihong;Lang, Zhijin;Hu, Jiani;Wu, Jianlin
通讯作者：
Wu, Jianlin
影响因子：
2.2
作者：
Duyn, Jeff
通讯作者：
Duyn, Jeff