Dissociable frontal controls during visible and memory-guided eye-tracking of moving targets.
Dissociable frontal controls during visible and memory-guided eye-tracking of moving targets.
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DOI：
10.1002/hbm.20777
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发表时间：
2009-11
影响因子：
4.8
通讯作者：
Jiang, Yang
中科院分区：
文献类型：
--
作者：
Ding, Jinhong;Powell, David;Jiang, Yang
在跟踪可见或遮挡的运动目标时，包括额叶眼区(FEF)、背侧前额叶皮质(DLPFC)和前扣带回皮质(ACC)在内的多个额叶区域参与平滑追踪眼动(SPEM)。为了研究这些区域在预测运动目标未来位置中的不同作用，12名健康大学生参与了一项视觉和遮挡目标的平滑追踪任务。同时记录他们的眼球运动和事件相关功能磁共振成像测量的脑反应。我们的结果表明，只有当运动点被遮挡时，不同的视觉线索才会导致物理追捕时间和估计追捕时间之间的时间差异。可见相速度增益高于闭塞相。我们发现，无论运动目标是可见的还是被遮挡的，双侧FEF都与眼球运动有关。然而，DLPFC和ACC在跟踪和预测遮挡运动目标的位置时表现出更强的活性，而在平滑跟踪可见目标时则受到抑制。当视觉线索越来越多时，在DLPFC和ACC中观察到的激活较少。此外，DLPFC存在显著的半球效应，右侧DLPFC在追逐被遮挡的运动目标时的反应显著高于左侧。相关结果表明，DLPFC，特别是右侧的DLPFC，在跟踪遮挡运动目标时(从记忆中)与FEF进行了更多的交流。在跟踪可见目标的过程中，ACC更多地调节FEF(可能与视觉注意有关)。我们的结果表明，在视觉和记忆引导的眼动目标跟踪中，DLPFC和ACC对FEF和皮层网络的调制是不同的。
When tracking visible or occluded moving targets, several frontal regions including the frontal eye fields (FEF), dorsal-lateral prefrontal cortex (DLPFC), and Anterior Cingulate Cortex (ACC) are involved in smooth pursuit eye movements (SPEM). To investigate how these areas play different roles in predicting future locations of moving targets, twelve healthy college students participated in a smooth pursuit task of visual and occluded targets. Their eye movements and brain responses measured by event-related functional MRI were simultaneously recorded. Our results show that different visual cues resulted in time discrepancies between physical and estimated pursuit time only when the moving dot was occluded. Visible phase velocity gain was higher than that of occlusion phase. We found bilateral FEF association with eye-movement whether moving targets are visible or occluded. However, the DLPFC and ACC showed increased activity when tracking and predicting locations of occluded moving targets, and were suppressed during smooth pursuit of visible targets. When visual cues were increasingly available, less activation in the DLPFC and the ACC was observed. Additionally, there was a significant hemisphere effect in DLPFC, where right DLPFC showed significantly increased responses over left when pursuing occluded moving targets. Correlation results revealed that DLPFC, the right DLPFC in particular, communicates more with FEF during tracking of occluded moving targets (from memory). The ACC modulates FEF more during tracking of visible targets (likely related to visual attention). Our results suggest that DLPFC and ACC modulate FEF and cortical networks differentially during visible and memory-guided eye tracking of moving targets.
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早期视觉皮层中额叶信号的自下而上的门控。
DOI：
10.1126/science.1153276
发表时间：
2008-07-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ekstrom LB;Roelfsema PR;Arsenault JT;Bonmassar G;Vanduffel W
通讯作者：
Vanduffel W
影响因子：
5.3
作者：
Chou, IH;Lisberger, SG
通讯作者：
Lisberger, SG
影响因子：
2
作者：
Haller, Sven;Fasler, David;Greenlee, Mark W.
通讯作者：
Greenlee, Mark W.
影响因子：
3.2
作者：
Jiang, Yang;Ding, Jinhong;Powell, David K.
通讯作者：
Powell, David K.
影响因子：
2.9
作者：
Kawawaki, D;Shibata, T;Kawato, M
通讯作者：
Kawato, M