Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer.
Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer.
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DOI：
10.1021/ja801631c
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发表时间：
2008-08-13
影响因子：
15
通讯作者：
Burda C
中科院分区：
文献类型：
--
作者：
Cheng Y;C Samia A;Meyers JD;Panagopoulos I;Fei B;Burda C
A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible “cage” that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP–Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
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影响因子：
3.9
作者：
Hone, DC;Walker, PI;Russell, DA
通讯作者：
Russell, DA
影响因子：
15
作者：
Hong, R;Han, G;Rotello, VM
通讯作者：
Rotello, VM
DOI：
10.1016/j.jphotochem.2006.08.024
发表时间：
2007-02-25
影响因子：
4.3
作者：
Musil, Zbynek;Zimcik, Petr;Lenco, Juraj
通讯作者：
Lenco, Juraj
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3.8
作者：
Paciotti, Giulio F.;Kingston, David G. I.;Tamarkin, Lawrence
通讯作者：
Tamarkin, Lawrence
影响因子：
46.9
作者：
Choi, Hak Soo;Liu, Wenhao;Frangioni, John V.
通讯作者：
Frangioni, John V.