Drosophila egg chamber elongation: insights into how tissues and organs are shaped.
Drosophila egg chamber elongation: insights into how tissues and organs are shaped.
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作者：
Gates J
随着组织和器官的形成，它们获得了特定的形状，这在它们正常运作的能力中起着不可或缺的作用。一个相对简单的系统被用来研究组织和器官是如何形成的，那就是细长果蝇卵的形成。虽然一段时间以来人们已经知道果蝇卵的伸长需要极化细胞内基底肌动蛋白网络和极化基层蛋白细胞外网络之间的相互作用，但这些相互作用如何促进卵的伸长仍不清楚。最近使用实时成像技术的研究揭示了两个新的过程，即全局组织旋转和振荡的基础肌动球蛋白收缩，这为两个极化蛋白网络如何合作产生细长的卵子提供了重要的见解。这篇综述总结了参与果蝇卵子伸长的蛋白质，以及最近的工作如何有助于我们目前对卵子伸长如何实现的理解。
As tissues and organs are formed, they acquire a specific shape that plays an integral role in their ability to function properly. A relatively simple system that has been used to examine how tissues and organs are shaped is the formation of an elongated Drosophila egg. While it has been known for some time that Drosophila egg elongation requires interactions between a polarized intracellular basal actin network and a polarized extracellular network of basal lamina proteins, how these interactions contribute to egg elongation remained unclear. Recent studies using live imaging have revealed two novel processes, global tissue rotation and oscillating basal actomyosin contractions, which have provided significant insight into how the two polarized protein networks cooperate to produce an elongated egg. This review summarizes the proteins involved in Drosophila egg elongation and how this recent work has contributed to our current understanding of how egg elongation is achieved.
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