Neural changes associated with cerebellar tDCS studied using MR spectroscopy.
Neural changes associated with cerebellar tDCS studied using MR spectroscopy.
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DOI：
10.1007/s00221-018-5170-1
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发表时间：
2018-04
影响因子：
2
通讯作者：
Galea JM
中科院分区：
文献类型：
--
作者：
Jalali R;Chowdhury A;Wilson M;Miall RC;Galea JM
阳极小脑经颅直流电刺激(TDC)被认为可以增强运动学习，因此，被认为是一种有希望的治疗干预措施。然而，支持小脑tdcs效应的神经机制目前尚不清楚。我们用磁共振波谱(MRS)研究了与小脑TDCs相关的神经变化。34名健康受试者被分成两组，在视觉运动适应任务中同时接受阳极或假小脑TDCs。阳极组接受一次额外的MRS训练，在此过程中，测量了主要的抑制性和兴奋性神经递质：GABA和谷氨酸(Glu)在阳极化小脑TDCs前、中和后，但不包括行为任务。我们发现，与治疗前相比，在治疗后或治疗后，组内GABA或谷氨酸水平没有显著变化，然而，参与者之间存在很大程度的变异性。尽管小脑tdcs不影响视觉运动适应，但令人惊讶的是，小脑tdcs增加了运动记忆的保持，这与参与者在tdcs期间小脑谷氨酸水平的下降密切相关。这项工作为可能构成小脑TDC的神经机制提供了新的见解，但也揭示了在参与者之间和研究之间产生稳健影响的能力的局限性。
Anodal cerebellar transcranial direct current stimulation (tDCS) is known to enhance motor learning, and therefore, has been suggested to hold promise as a therapeutic intervention. However, the neural mechanisms underpinning the effects of cerebellar tDCS are currently unknown. We investigated the neural changes associated with cerebellar tDCS using magnetic resonance spectroscopy (MRS). 34 healthy participants were divided into two groups which received either concurrent anodal or sham cerebellar tDCS during a visuomotor adaptation task. The anodal group underwent an additional session involving MRS in which the main inhibitory and excitatory neurotransmitters: GABA and glutamate (Glu) were measured pre-, during, and post anodal cerebellar tDCS, but without the behavioural task. We found no significant group-level changes in GABA or glutamate during- or post-tDCS compared to pre-tDCS levels, however, there was large degree of variability across participants. Although cerebellar tDCS did not affect visuomotor adaptation, surprisingly cerebellar tDCS increased motor memory retention with this being strongly correlated with a decrease in cerebellar glutamate levels during tDCS across participants. This work provides novel insights regarding the neural mechanisms which may underlie cerebellar tDCS, but also reveals limitations in the ability to produce robust effects across participants and between studies.
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DOI：
10.1523/jneurosci.2184-09.2009
发表时间：
2009-07-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Galea JM;Jayaram G;Ajagbe L;Celnik P
通讯作者：
Celnik P
影响因子：
3.1
作者：
Avila, Eric;van der Geest, Jos N.;Frens, Maarten A.
通讯作者：
Frens, Maarten A.
影响因子：
2.9
作者：
Hunter, Michael A.;Coffman, Brian A.;Gasparovic, Charles;Calhoun, Vince D.;Trumbo, Michael C.;Clark, Vincent P.
通讯作者：
Clark, Vincent P.
在冲突任务中，阳极经颅直流电流刺激对与响应相关的ERP没有影响。
影响因子：
2.9
作者：
Conley AC;Fulham WR;Marquez JL;Parsons MW;Karayanidis F
通讯作者：
Karayanidis F
影响因子：
4.2
作者：
Hardwick RM;Celnik PA
通讯作者：
Celnik PA