Behavior Model for Assessing Decline in Executive Function During Aging and Neurodegenerative Diseases.

Behavior Model for Assessing Decline in Executive Function During Aging and Neurodegenerative Diseases.
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用于评估衰老和神经退行性疾病期间执行功能下降的行为模型。

DOI:
10.1007/978-1-4939-9554-7_26
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发表时间:
2019
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Kumar,Ashok
Kumar,Ashok
中科院分区:
--
文献类型:
--
作者:
Yegla,Brittney;Foster,ThomasC;Kumar,Ashok

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执行功能障碍是几种精神和神经退行性疾病的特征。有趣的是,由前额叶皮层(PFC)介导的执行功能通常会在衰老过程中下降。注意定势转换任务(AST)是一种广泛用于评估啮齿类、灵长类和人类执行功能的任务。如果使用得当,这项任务可以从行为上评估注意力、反应抑制和认知灵活性。以下部分使用与年龄相关的执行功能下降的研究来展示所采用的方法,并强调如果使用不当可能会混淆研究的领域。
Executive dysfunction is a characteristic of several psychiatric and neurodegenerative diseases. Interestingly, executive function, which is mediated by the prefrontal cortex (PFC), commonly declines during aging. The attentional set-shifting task (AST) is commonly and extensively used to assess executive function in rodents, primates, and humans. When properly employed, this task can behaviorally assess attention, response inhibition, and cognitive flexibility. The following section uses research on age-related decline in executive function to demonstrate the methods employed and highlight areas that can confound a study if not employed properly.
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