Effect of individual- versus collective-based nutritional-lifestyle intervention on the atherogenic index of plasma in children with obesity: a randomized trial.
Effect of individual- versus collective-based nutritional-lifestyle intervention on the atherogenic index of plasma in children with obesity: a randomized trial.
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基于个体与基于群体的营养生活方式干预对肥胖儿童血浆致动脉粥样硬化指数的影响：一项随机试验
DOI：
10.1186/s12986-020-00537-w
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发表时间：
2021-01-13
影响因子：
4.5
通讯作者：
Radaelli G
中科院分区：
文献类型：
--
作者：
Verduci E;Banderali G;Di Profio E;Vizzuso S;Zuccotti G;Radaelli G
血浆致动脉粥样硬化指数（AIP）是成人动脉粥样硬化的一种预测性生物标志物，但在儿科人群中缺乏旨在评估AIP以及与营养干预相关的心脏代谢血液指标纵向变化的研究。本研究的目的是比较基于个体和基于群体的营养生活方式干预对肥胖学龄儿童血浆致动脉粥样硬化指数的影响。
164名年龄在6 - 12岁、体重指数z评分>2的儿童被转诊至意大利米兰圣保罗医院儿童肥胖门诊，并被连续纳入研究，随机接受基于个体（n = 82）或基于群体（n = 82）的干预，以促进均衡的正常热量饮食和身体活动。此外，个体干预包括基于修订后的考文垂、阿伯丁和伦敦细化分类法的定制个性化营养建议和教育。在基线时以及干预12个月后，评估饮食习惯和人体测量指标，并采集空腹血样进行生化分析。
12个月时的参与率为93.3%（n = 153名患者），个体干预组有76名儿童，群体干预组有77名儿童。单变量分析显示，个体干预组血浆致动脉粥样硬化指数的平均纵向变化大于群体干预组（-0.12比 - 0.05），甘油三酯 - 葡萄糖指数的变化（-0.22比 - 0.08）以及体重指数z评分的变化（-0.59比 - 0.37）也是如此。多变量分析显示，只有体重指数z评分的变化与干预独立相关（比值比3.37）。
在肥胖儿童中，基于个体的营养和生活方式干预，包括来自CALO - RE分类法的技术，可能比基于群体的干预具有额外的有益效果，尽管这种效果的实际大小仍有待阐明。
试验注册：临床试验NCT03728621
The Atherogenic Index of Plasma is a predictive biomarker of atherosclerosis in adults but there is a lack of studies in paediatric population aimed at evaluating the longitudinal changes of the AIP and of the cardiometabolic blood profile related to nutritional interventions. The aim of this study was to compare the effect of individual- versus collective-based nutritional-lifestyle intervention on the Atherogenic Index of Plasma in schoolchildren with obesity. One-hundred sixty-four children aged 6–12 years with Body Mass Index z-score > 2 referred to the Paediatric Obesity Clinic, San Paolo Hospital, Milan, Italy, were consecutively enrolled and randomized to undergo to either an individual- (n = 82) or a collective- (n = 82) based intervention promoting a balanced normo-caloric diet and physical activity. In addition, the individual intervention included a tailored personalized nutritional advice and education based on the revised Coventry, Aberdeen, and London-Refined taxonomy. Both at baseline and after 12 months of intervention, dietary habits and anthropometric measures were assessed, a fasting blood sample were taken for biochemistry analysis. The participation rate at 12 months was 93.3% (n = 153 patients), 76 children in the individual-intervention and 77 children in the collective intervention. At univariate analysis, mean longitudinal change in Atherogenic Index of Plasma was greater in the individual than collective intervention (− 0.12 vs. − 0.05), as well as change in triglyceride-glucose index (− 0.22 vs. − 0.08) and Body Mass Index z-score (− 0.59 vs. − 0.37). At multiple analysis, only change in Body Mass Index z-score remained independently associated with intervention (odds ratio 3.37). In children with obesity, an individual-based nutritional and lifestyle intervention, including techniques from the CALO-RE taxonomy, could have an additional beneficial effect over a collective-based intervention, although the actual size of the effect remains to be clarified. Trial Registration Clinical Trials NCT03728621
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影响因子：
2.6
作者：
Cook, Stephen;Kavey, Rae Ellen W.
通讯作者：
Kavey, Rae Ellen W.
影响因子：
4.9
作者：
Kang, B.;Yang, Y.;Yoon, K-H
通讯作者：
Yoon, K-H
影响因子：
2.8
作者：
D'Adamo E;Guardamagna O;Chiarelli F;Bartuli A;Liccardo D;Ferrari F;Nobili V
通讯作者：
Nobili V
影响因子：
3.2
作者：
Bach-Faig, Anna;Berry, Elliot M.;Serra-Majem, Lluis
通讯作者：
Serra-Majem, Lluis
影响因子：
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作者：
Ford, ES;Liu, SM
通讯作者：
Liu, SM